Role of tachykinins in castor oil diarrhoea in rats

British Journal of Pharmacology
T CrociL Manara

Abstract

1. We set out to ascertain the role of tachykinins, neurokinin A and substance P, in castor oil-induced diarrhoea in rats as disclosed by the inhibitory effect of the non-peptide NK1- and NK2-receptor antagonists. SR 140333 and SR 48968, respectively. 2. SR 48968 (0.02 to 20 micrograms kg-1, s.c. or p.o.), and the opioid receptor agonist loperamide (1-10 mg kg-1, p.o.), dose-dependently prevented castor oil effects: % inhibition vs castor oil, diarrhoea 0 to 100, increase in faecal mass 7 to 90 and water content 16 to 90. SR 140333 (0.02 to 20 micrograms kg-1, s.c.) and the platelet activating factor antagonist SR 27417 (5 to 500 micrograms kg-1, p.o.) did not prevent the increase in faecal water content, but reduced faecal mass (35 to 66%) and diarrhoea (0 to 57%). 3. The R-enantiomers of tachykinin NK1 and NK2 receptor antagonists, SR 140603 and SR 48605 (both at 2 or 20 micrograms kg-1, s.c.) had no effect other than reducing faecal mass at the highest dose tested. 4. SR 48968 (20 micrograms kg-1, p.o.) but not loperamide (10 mg kg-1, p.o.) given 24 h before castor oil, still slightly but significantly reduced by 30% the increase of faecal mass output; both treatments significantly reduced (30 to 70%) the effect of castor oi...Continue Reading

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Citations

Sep 28, 2005·Digestive Diseases and Sciences·Muhammad Nabeel Ghayur, Anwarul Hassan Gilani
Nov 8, 2001·European Journal of Pharmacology·R Patacchini, C A Maggi
Mar 30, 1999·European Journal of Pharmacology·A A IzzoF Capasso
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Oct 21, 2011·Natural Product Research·Arif-ullah Khan, Anwarul Hassan Gilani
Nov 16, 2011·Journal of Medicinal Food·Esam Y QnaisShtaywy S Abdalla
Nov 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Daniel Zavala-MendozaMiguel A Zavala-Sánchez
Feb 1, 2008·European Journal of Pharmacology·Dorota Kakol-PalmErik Lindström
Feb 22, 2008·Journal of Ethnopharmacology·Anwarul Hassan GilaniSaad Ajmal
Mar 24, 2004·British Journal of Pharmacology·Alessandro LecciCarlo Alberto Maggi
Nov 2, 2006·Basic & Clinical Pharmacology & Toxicology·Anwarul Hassan GilaniJoachim W Herzig
Jul 5, 2012·Phytotherapy Research : PTR·Hafiz Muhammad Abdur RahmanAnwarul Hassan Gilani
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