Role of tartrate-resistant acid phosphatase (TRAP) in long bone development.

Mechanisms of Development
Michael J F BlumerHelga Fritsch

Abstract

Tartrate resistant acid phosphatase (TRAP) was shown to be critical for skeleton development, and TRAP deficiency leads to a reduced resorptive activity during endochondral ossification resulting in an osteopetrotic phenotype and shortened long bones in adult mice. A proper longitudinal growth depends on a timely, well-coordinated vascularization and formation of the secondary ossification center (SOC) of the long bones epiphysis. Our results demonstrate that TRAP is not essential for the formation of the epiphyseal vascular network. Therefore, in wild type (Wt) controls as well as TRAP deficient (TRAP(-/-)) mutants vascularised cartilage canals are present from postnatal day (P) five. However, in the epiphysis of the TRAP(-/-) mice cartilage mineralization, formation of the marrow cavity and the SOC occur prematurely compared with the controls. In the mutant mice the entire growth plate is widened due to an expansion of the hypertrophic zone. This is not seen in younger animals but first detected at week (W) three and during further development. Moreover, an enhanced number of thickened trabeculae, indicative of the osteopetrotic phenotype, are observed in the metaphysis beginning with W three. Epiphyseal excavation was propos...Continue Reading

References

Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F P ReinholtD Heinegård
Jan 1, 1969·Journal of Ultrastructure Research·A R Spurr
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z ZhouK Tryggvason
Sep 28, 2002·Journal of Neuroscience Methods·Michael J F BlumerB Ruthensteiner
Jan 1, 1959·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M S BURSTONE
Oct 31, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alison R Hayman, Timothy M Cox
Apr 23, 2004·Trends in Cell Biology·Nathalie OrtegaZena Werb
Aug 18, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xu-Ming DaiE Richard Stanley
May 11, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jesús AlvarezJosé M López
Nov 1, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tamara A Franz-OdendaalP Eckhard Witten
Jan 27, 2006·The American Journal of Pathology·Tajneen NatashaSusan R Rittling
Apr 20, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Kenn Holmbeck, Ludmila Szabova
May 15, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Zenjiro MaruyamaToshihisa Komori
Jul 13, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Michael J F BlumerHelga Fritsch
Dec 1, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ahnders FranzénDick Heinegård
Jul 8, 2008·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Michael J F BlumerHelga Fritsch
May 15, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Eunice R LeeJohn S Mort
Jun 9, 2010·Journal of Anatomy·Doris AllerstorferMichael J F Blumer

❮ Previous
Next ❯

Citations

Mar 1, 2018·Journal of Anatomy·Gernot SchmidleMarkus Gabl
Jun 15, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Shunichi ShibataKaoru Fujikawa
Jan 11, 2020·Journal of Cellular and Molecular Medicine·Md Abdullah Al MamunMd Abdul Alim Al-Bari
Jun 11, 2017·Journal of Tissue Engineering and Regenerative Medicine·Johnathan NgGordana Vunjak-Novakovic
Sep 6, 2017·The Journal of Pharmacy and Pharmacology·Daphne P L Lin, Crispin R Dass
Mar 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jane Y SongDeneen M Wellik
Nov 24, 2019·Scientific Reports·Peerapat VisitchanakunSutada Lotinun
Oct 9, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Richard KomakechYoungmin Kang
Feb 19, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Michael J F Blumer
Apr 20, 2021·Biomedical Materials·Ayomiposi M LoyeThemis R Kyriakides

❮ Previous
Next ❯

Software Mentioned

WindowsXP
MetaMorph®

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.