Role of taste and calories in the selection of ethanol by C57BL/6NHsd and Hsd:ICR mice

Alcohol
B A McMillen, H L Williams

Abstract

The C57BL/6 mouse (C57) is used as a model for the human consumption of ethanol. Previous studies on the taste preferences of the C57 mouse indicate that ethanol drinking by this animal is for calories and not for a pharmacological effect. The purpose of this study, therefore, was to further determine the role of calories and taste in the selection of ethanol by the C57 mouse. C57 and outbred Hsd:ICR (ICR or CD-1) mice were housed two per cage with three drinking tubes. A standard 10-day preference test of 3-30% ethanol (v/v) vs. water was performed: the mean maximally preferred concentrations of ethanol were 17.9% for C57 and 6.8% for ICR mice. Once drinking of the preferred concentration for each cage had stabilized at 13.2 and 0.9 g/kg/day, respectively, the third tube was filled with water, 0.5% aspartame, isocaloric dextrose, or diluted chocolate Ultra Slim-Fast plus dextrose. Five days of dextrose or chocolate drink reduced the amount of ethanol consumed by 41% and 44% by C57 mice, but aspartame did not affect their drinking. Additional groups of C57 and ICR mice were habituated to a 2-h limited access to water. When offered a 0.5 mM quinine solution as the only fluid, both strains consumed the same volumes as water. Pres...Continue Reading

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Citations

Mar 10, 2001·Physiology & Behavior·R D Mattes, D DiMeglio
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·William J McBride
Nov 25, 2000·Alcohol·B A McMillen
Aug 30, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Eli O Meltzer, Hartmut Derendorf
Feb 20, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David I Bernstein, David B Allen
Mar 31, 2012·Traffic Injury Prevention·Chidi Ogazi, Ema Edison
Aug 19, 2007·Chemical Senses·Theresa L WhiteSteven L Youngentob
Dec 17, 2009·Addiction Biology·Yuri A BlednovAdron R Harris
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·D D RasmussenS Puchalski
Oct 18, 2007·BMC Neuroscience·John D Boughter, Alexander A Bachmanov
Sep 10, 2004·The European Journal of Neuroscience·Ryan K BachtellAndrey E Ryabinin
Apr 1, 2006·Alcoholism, Clinical and Experimental Research·Jennifer Lynn ShortAndrew John Lawrence
Jul 1, 2010·Alcoholism, Clinical and Experimental Research·Simranjit Kaur, Andrey E Ryabinin
Feb 27, 2003·Alcoholism, Clinical and Experimental Research·Alexander A BachmanovJulie A Mennella
Dec 28, 2016·The Journal of Pathology·Mike F MüllerMark J Arends

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