PMID: 38317Jul 1, 1979

Role of taurine as a possible transmitter in the thermoregulatory pathways of the rat

The Journal of Pharmacy and Pharmacology
R W Kerwin, C J Pycock

Abstract

Taurine (10 and 20 micrograms) injected unilaterally into the lateral ventricle of rats caused an increase in core temperature. Bilateral injection of taurine 2.5 and 5 micrograms into the preoptic region of the anterior hypothalamus induced a dose-related hyperthermia: higher doses (10 micrograms) caused hypothermia. Intrahypothalamically taurine-induced hyperthermia was blocked by prior injection of strychnine hydrochloride (5 and 15 micrograms); doses which alone had no effect on core temperature. Of the other inhibitory amino acids injected intrahypothalamically hypotaurine also induced a hyperthermia. GABA (10 micrograms) caused hypothermia; glycine (10 micrograms) had no effect. Potassium (50 mM) stimulated release of radioactivity from superfused slices of anterior hypothalamus prelabelled with [3H]taurine in a calcium-dependent manner. A high affinity uptake mechanism with a Km of 8.5 microM was demonstrated with [3H]taurine into slices of anterior hypothalamus. Taurine may have a neurotransmitter role in the anterior hypothalamus but whether the body temperature effects represent physiological or pharmacological events remains to be established.

References

Jan 1, 1975·Annual Review of Pharmacology·F V DeFeudis
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Citations

Jan 1, 1980·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·B BauerL Aberg
Jan 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R W ChesneyS Dabbagh
Jan 1, 1989·Neurochemical Research·R A PhilibertG R Dutton
Feb 17, 1984·European Journal of Pharmacology·P BousquetJ Schwartz
Jan 1, 1989·Progress in Neurobiology·R J Huxtable
Oct 30, 1990·Neuroscience Letters·G A TiggesG R Dutton
Aug 1, 1985·Acta Pharmacologica Et Toxicologica·L AhteeJ Halmekoski

Related Concepts

Heat Loss
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Supraoptic Hypothalamus
Strychnine Nitrate
Taurine, Monopotassium Salt

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