Feb 6, 2004

Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections

Nature Medicine
Christopher WeidenmaierAndreas Peschel

Abstract

Colonization of the anterior nares in approximately 37% of the population is a major risk factor for severe Staphylococcus aureus infections. Here we show that wall teichoic acid (WTA), a surface-exposed staphylococcal polymer, is essential for nasal colonization and mediates interaction with human nasal epithelial cells. WTA-deficient mutants were impaired in their adherence to nasal cells, and were completely unable to colonize cotton rat nares. This study describes the first essential factor for S. aureus nasal colonization.

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References

  • References14
  • Citations308

Citations

Mentioned in this Paper

Nasal Epithelium
Sigmodon
Eosinophilic Non-allergic Rhinitis
Squamous Transitional Epithelial Cell Count
Thylacodes aureus
Nares, Entire, Anterior or Posterior
Genus staphylococcus
Staphylococcal Infections
Sigmodontinae
Styrax aureus

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