Role of terminal and anastomotic circulation in the patency of arteries jailed by flow-diverting stents: animal flow model evaluation and preliminary results

Journal of Neurosurgery
Christina IosifCharbel Mounayer

Abstract

OBJECTIVE The authors describe herein the creation of an animal model capable of producing quantifiable data regarding blood flow rate and velocity modifications in terminal and anastomotic types of cerebrofacial circulation. They also present the preliminary results of a translational study aimed at investigating the role of terminal and anastomotic types of circulation in arterial branches jailed by flow-diverting stents as factors contributing to arterial patency or occlusion. METHODS Two Large White swine were used to validate a terminal-type arterial model at the level of the right ascending pharyngeal artery (APhA), created exclusively by endovascular means. Subsequently 4 Large White swine, allocated to 2 groups corresponding to the presence (Group B) or absence (Group A) of terminal-type flow modification, underwent placement of flow-diverting stents. Blood flow rates and velocities were quantified using a dedicated time-resolved 3D phase-contrast MRA sequence before and after stenting. Three months after stent placement, the stented arteries were evaluated with digital subtraction angiography (DSA) and scanning electron microscopy (SEM). Patent (circulating) ostia quantification was performed on the SEM images. RESULTS...Continue Reading

References

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Oct 16, 2012·Journal of Biomechanics·Gábor JanigaDominique Thévenin
Jan 17, 2013·Stroke; a Journal of Cerebral Circulation·Waleed BrinjikjiDavid F Kallmes
Jun 5, 2013·Biomedizinische Technik. Biomedical Engineering·Gábor JanigaDominique Thévenin
Oct 26, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Rishi R LallDavid F Kallmes
Nov 21, 2013·Stroke; a Journal of Cerebral Circulation·Nohra ChalouhiPascal Jabbour
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Apr 16, 2014·Clinical Neurology and Neurosurgery·Waleed BrinjikjiDavid F Kallmes
Aug 15, 2014·Neurosurgery·Suzana SalemeCharbel Mounayer

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Citations

May 23, 2018·The International Journal of Artificial Organs·Philipp BergVitor M Pereira
Mar 24, 2018·Journal of Biomechanical Engineering·Andrea AcunaCraig J Goergen
Jan 5, 2020·Journal of Neurointerventional Surgery·Ana Paula NarataAlberto Marzo
Sep 8, 2018·Cardiovascular Engineering and Technology·Philipp BergOliver Beuing
Mar 1, 2017·Neuroradiology·Robert FahedJean Raymond

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Methods Mentioned

BETA
scanning electron microscopy
optical microscopy

Software Mentioned

ARRIVE
Statistica
ImageJ1
MeVisLab

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