PMID: 6166268Feb 1, 1981Paper

Role of testosterone levels and of hypophysis in the HCG-induced modifications of the 7 alpha-hydroxylation and 5 alpha-reduction processes in incubated rat testes

Archives internationales de physiologie et de biochimie
E LacroixI Leusen

Abstract

The role of a direct or a hypophysis-mediated influence of increased testosterone levels in the effects of a long-term high-dose HCG administration (10 IU/day) upon the 7 alpha-hydroxylation and 5 alpha-reduction activities of incubated testes of mature rats was investigated. Administration of high doses of HCG to hypophysectomized rats resulted in the same metabolic changes as in normal rats, namely, a large decrease in the 7 alpha-hydroxylation and an increase in the 5 alpha-reduction processes. Administration of testosterone-propionate (0.2 mg and 20 mg/day) for several days to hypophysectomized rats and to normal rats receiving and substitutive dose of 1 IU HCG/day, did not modify the testicular metabolization pattern. These findings indicate that the decrease in testicular 7 alpha-hydroxylation activity induced by long-term administration of high doses of HCG is probably not mediated by the hypophysis nor by the extracellular testosterone levels.

References

Mar 1, 1975·Journal of Steroid Biochemistry·S N NayfehF S French
Apr 1, 1977·Journal of Steroid Biochemistry·E LacroixI Leusen
Mar 1, 1975·Journal of Steroid Biochemistry·G J Van Der VusseH J Van Der Molen
Sep 1, 1966·Endocrinology·H Inano, B I Tamaoki

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