Role of TGF-β signalling in PCOS associated focal segmental glomerulosclerosis.

Clinica Chimica Acta; International Journal of Clinical Chemistry
Monica BhatiAbilash Valsala Gopalakrishnan

Abstract

Research on polycystic ovarian syndrome (PCOS) remains intense due to its evolving impact on metabolism, reproduction and cardiovascular function. Changes in metabolic pathways can also significantly impact renal function including the development of Focal Segmental Glomerulosclerosis (FSGS), one of the most highly investigated renal diseases. In FSGS, scarring of the glomerulus vascular tuft damages the kidneys. Onset of FSGS may either be congenital or due to other disorders that affect the metabolism and normal kidney function. Both PCOS and FSGS appear to be associated with Transforming Growth Factor-β (TGF-β) signalling. Over-expression of TGF-β may be due to the activation of the thrombospondin 1 (TSP1) gene, which increases the probability of developing renal disorders. Higher androgen levels in PCOS may also cause podocyte damage thus directly impacting development of FSGS. This article reviews the role of TGF-β's in PCOS and FSGS and explores the inter-relationship between these two disorders.

References

Mar 1, 1993·Kidney International·P H LaneS M Mauer
Feb 11, 1998·Fertility and Sterility·W X LiaoS S Ratnam
Jun 5, 1998·The International Journal of Biochemistry & Cell Biology·D A Clark, R Coker
Mar 22, 2001·Kidney International·N KambhamV D D'Agati
Jun 1, 2001·Journal of the Royal Society of Medicine·V C BlackwellR J Unwin
Dec 17, 2002·Journal of Cell Science·Justin P AnnesDaniel B Rifkin
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·M QuinklerS Diederich
Oct 9, 2003·Kidney International·Ji Hoon KimHyun Soon Lee
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Jan 14, 2004·Kidney International·Christoph DanielChristian Hugo
Mar 16, 2004·Human Reproduction·Roy Homburg, Cornelius B Lambalk
Apr 22, 2004·American Journal of Physiology. Renal Physiology·Albert QuanRaymond Quigley
Aug 17, 2004·Critical Reviews in Clinical Laboratory Sciences·Marko HyytiäinenJorma Keski-Oja
Jan 11, 2005·Current Vascular Pharmacology·Alex AgrotisAlex Bobik
Mar 25, 2005·The New England Journal of Medicine·David A Ehrmann
Aug 9, 2005·Endocrinology and Metabolism Clinics of North America·Colleen Buggs, Robert L Rosenfield
Dec 16, 2005·The American Journal of the Medical Sciences·Rubin ZhangEfrain Reisin
Mar 30, 2006·Current Rheumatology Reports·Martin A KriegelRichard A Flavell
Jun 27, 2006·Fertility and Sterility·Charles Sultan, Françoise Paris
Oct 19, 2006·Advances in Chronic Kidney Disease·Will R Ross, Janet B McGill
Jan 12, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kimberly Reidy, Frederick J Kaskel
Aug 29, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Gérald J Prud'homme
Sep 6, 2007·The Journal of Clinical Endocrinology and Metabolism·Margrit UrbanekAndrea Dunaif
Mar 4, 2008·Biochimica Et Biophysica Acta·Kelly J Gordon, Gerard C Blobe
Mar 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alejandro F Castro, Josef Coresh
Jun 23, 2009·Biochimica Et Biophysica Acta·Dirk PohlersGunter Wolf
Jun 4, 2010·Pediatric Transplantation·Modini VinaiMouin G Seikaly
Sep 16, 2010·Annals of the New York Academy of Sciences·Vincenzina BruniDaniela Nuvolone
Sep 22, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Diana JordanLynn Y Sakai
Jan 7, 2011·Néphrologie & thérapeutique·Maurice Laville
Jul 13, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Jeroen T BuijsTheresa A Guise
Nov 26, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·David UnuaneKris Poppe
Dec 21, 2011·Cell and Tissue Research·K KrieglsteinK Unsicker

❮ Previous
Next ❯

Citations

Mar 29, 2021·Life Sciences·Yogamaya D Prabhu, Abilash Valsala Gopalakrishnan
Oct 27, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lijun Zhang, Wangsen Cao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Netherlands Journal of Medicine
J K J DeegensJack F M Wetzels
Clinical Journal of the American Society of Nephrology : CJASN
Avi Z Rosenberg, Jeffrey B Kopp
© 2021 Meta ULC. All rights reserved