PMID: 9179210May 1, 1997Paper

Role of thallium-201 chloride and Tc-99m methoxy-isobutyl-isonitrite (sestaMIBI) in evaluation of breast masses: correlation with the immunohistochemical characteristic parameters (Ki-67, PCNA, Bcl, and angiogenesis) in malignant lesions

Anticancer Research
W S OmarH M Abdel-Dayem

Abstract

The aim of this project was to study the kinetics of both Tl and Tc-99m MIBI in PBM by evaluating tumor to normal tissue ratio in early (E) images acquired within 1/2 hour and delayed (D) images acquired three hours following the i.v. injection of 3 mCi (111 MBq) of Tl and 20 mCi (740 MBq) of MIBI on 2 separate days in 49 patients. The washout index was calculated from E ratio minus D ratio divided by E ratio. A negative ratio indicating build up of activity in D images and a positive ratio indicated washout of activity from the E images. In addition, the findings were correlated with the following immunohistochemical parameters: pathological grading, number of cells in mitotic division (PCNA- Ki-67), angiogenesis (well formed and ill formed blood vessels) and presence or absence of Bcl 2 Oncogene (release antiapoptotic signals). Results showed that in all benign and malignant lesions, MIBI showed consistent washout varying from 19-27% while with Tl, there was persistent washout in all benign lesions and mixed washout or buildup varying from +16% to minus 17% in malignant lesions, (E) ratios showed a reasonable correlation between Tl and MIBI (r = 0.5). There was more significant correlation between the D ratios (r = 0.8). Due ...Continue Reading

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