Role of the -adrenoceptor in regulating noradrenaline overflow by nerve stimulation

British Journal of Pharmacology
M A EneroF J Stefano


1. A study of the actions of phenoxybenzamine on transmitter overflow, neuronal and extraneuronal uptake of noradrenaline and in causing alpha-adrenoceptor blockade was carried out using the isolated cat nictitating membrane preparation.2. Phenoxybenzamine increased transmitter overflow elicited by nerve-stimulation at 10 Hz in a concentration dependent manner in the range 10(-8) to 10(-5) g/ml.3. Neuronal uptake of [(3)H]-noradrenaline was not inhibited by concentrations lower than 10(-6) g/ml of phenoxybenzamine. With 10(-7) g/ml of phenoxybenzamine a significant increase in transmitter overflow was obtained, although neuronal uptake of noradrenaline was not affected. Higher concentrations of phenoxybenzamine (10(-6) and 10(-5) g/ml) inhibited the neuronal uptake of noradrenaline and further increased transmitter overflow.4. Extraneuronal uptake of [(3)H]-noradrenaline was inhibited only with the highest concentration of phenoxybenzamine tested (10(-5) g/ml) and therefore appears to be unrelated to the effects on transmitter overflow.5. There was a significant correlation between the degree of alpha-adrenoceptor block produced by phenoxybenzamine and the increase in transmitter overflow obtained by nerve stimulation.6. These ...Continue Reading


Jan 1, 1969·Naunyn-Schmiedebergs Archiv Für Pharmakologie·K Löffelholz, E Muscholl
Jan 1, 1969·Acta Physiologica Scandinavica·J Häggendal, T Malmfors
Apr 1, 1971·The Journal of Physiology·S Z Langer, M Vogt
Jul 1, 1970·British Journal of Pharmacology·S M Kirpekar, A R Wakade
Jan 1, 1967·Annual Review of Pharmacology·C B Ferry
Nov 1, 1969·British Journal of Pharmacology·S L Lightman, L L Iversen
Jan 1, 1967·Acta Physiologica Scandinavica. Supplementum·O Lundgren
Aug 29, 1957·The Journal of Physiology·G L BROWN, J S GILLESPIE
Apr 3, 1958·The Journal of Physiology·J W THOMPSON
Jul 1, 1963·The Journal of Physiology·A G BLAKELEYC B FERRY
Aug 1, 1963·The American Journal of Physiology·S ROSELLJ AXELROD
Dec 1, 1963·British Journal of Pharmacology and Chemotherapy·L L IVERSEN
Apr 21, 1964·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·J R CROUT

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