Role of the -adrenoceptor in regulating noradrenaline overflow by nerve stimulation

British Journal of Pharmacology
M A EneroF J Stefano

Abstract

1. A study of the actions of phenoxybenzamine on transmitter overflow, neuronal and extraneuronal uptake of noradrenaline and in causing alpha-adrenoceptor blockade was carried out using the isolated cat nictitating membrane preparation.2. Phenoxybenzamine increased transmitter overflow elicited by nerve-stimulation at 10 Hz in a concentration dependent manner in the range 10(-8) to 10(-5) g/ml.3. Neuronal uptake of [(3)H]-noradrenaline was not inhibited by concentrations lower than 10(-6) g/ml of phenoxybenzamine. With 10(-7) g/ml of phenoxybenzamine a significant increase in transmitter overflow was obtained, although neuronal uptake of noradrenaline was not affected. Higher concentrations of phenoxybenzamine (10(-6) and 10(-5) g/ml) inhibited the neuronal uptake of noradrenaline and further increased transmitter overflow.4. Extraneuronal uptake of [(3)H]-noradrenaline was inhibited only with the highest concentration of phenoxybenzamine tested (10(-5) g/ml) and therefore appears to be unrelated to the effects on transmitter overflow.5. There was a significant correlation between the degree of alpha-adrenoceptor block produced by phenoxybenzamine and the increase in transmitter overflow obtained by nerve stimulation.6. These ...Continue Reading

References

Jan 1, 1969·Naunyn-Schmiedebergs Archiv Für Pharmakologie·K Löffelholz, E Muscholl
Jan 1, 1969·Acta Physiologica Scandinavica·J Häggendal, T Malmfors
Apr 1, 1971·The Journal of Physiology·S Z Langer, M Vogt
Jul 1, 1970·British Journal of Pharmacology·S M Kirpekar, A R Wakade
Jan 1, 1967·Annual Review of Pharmacology·C B Ferry
Nov 1, 1969·British Journal of Pharmacology·S L Lightman, L L Iversen
Jan 1, 1967·Acta Physiologica Scandinavica. Supplementum·O Lundgren
Aug 29, 1957·The Journal of Physiology·G L BROWN, J S GILLESPIE
Apr 3, 1958·The Journal of Physiology·J W THOMPSON
Jul 1, 1963·The Journal of Physiology·A G BLAKELEYC B FERRY
Aug 1, 1963·The American Journal of Physiology·S ROSELLJ AXELROD
Dec 1, 1963·British Journal of Pharmacology and Chemotherapy·L L IVERSEN
Apr 21, 1964·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·J R CROUT

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Citations

Sep 12, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·L F Tseng
Dec 29, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·J R Walters, R H Roth
Feb 26, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·A A BorbélyP G Waser
Jul 17, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·C J PerecO R Tumilasci
Jan 1, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·M Dubocovich, S Z Langer
Jun 20, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·M A Enero, S Z Langer
Jan 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·A R Wakade, T D Wakade
Jul 26, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·A PhilippuH Przuntek
May 17, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·K Starke, H Montel
Aug 24, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·K Starke, H Montel
May 28, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·Y Gutman, P Boonyaviroj
May 28, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·M C Koss, H D Christensen
Jun 21, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·P Hedqvist, B B Fredholm
Mar 14, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·M A Enero, B Q Saidman
Jul 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·T Hölting, K Starke
Jan 1, 1977·Journal of Neural Transmission·Y Gutman, P Boonyaviroj
Aug 17, 2006·Journal of Physiology and Biochemistry·I Márquez-RodasG Balfagón
Mar 1, 1973·European Journal of Pharmacology·S BergströmK Fuxe
Oct 1, 1974·European Journal of Pharmacology·Y Gutman, P Boonyaviroj
Aug 1, 1975·European Journal of Pharmacology·M IlhanJ G Cannon
Sep 1, 1975·European Journal of Pharmacology·B J Van Zwieten-Boot, E L Noach
Nov 15, 1977·European Journal of Pharmacology·W HopeM J Rand
Oct 15, 1977·European Journal of Pharmacology·M A Enero
Aug 15, 1977·European Journal of Pharmacology·J M Cedarbaum, G K Aghajanian
Jan 7, 1977·European Journal of Pharmacology·P Boonyaviroj, Y Gutman
Jan 7, 1977·European Journal of Pharmacology·S Z Langer, M L Dubocovich
May 15, 1978·European Journal of Pharmacology·S Kunitada, M Ui
Jan 1, 1974·Journal of Psychiatric Research·P B Molinoff
Jan 1, 1978·General Pharmacology·A G Blakeley, R J Summers
Jan 1, 1979·General Pharmacology·B D Bhagat

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