Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice

Journal of Pharmacological Sciences
Shigeru HasebeToshio Matsuda

Abstract

We have found that fluvoxamine-induced increases in prefrontal dopamine release are enhanced by adrenalectomy/castration and 5-HT1A receptors are involved in the enhancement. This study examined which 5-HT1A autoreceptors or postsynaptic receptor play a key role in the enhancement in mice. Adrenalectomy/castration-induced enhancement of fluvoxamine-induced increase in the dopamine release was not blocked by local perfusion with the 5-HT1A receptor antagonist WAY100635 (10 μM), while it was blocked by systemic administration of WAY100635 at low dose (0.1 mg/kg) which blocked preferentially autoreceptor-mediated responses. These finding suggests that 5-HT1A autoreceptors play a key role in the enhancement of prefrontal dopamine release.

References

Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Dec 5, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susanne KochFrank P Bymaster
Feb 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kenji HashimotoMasaomi Iyo
Feb 22, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yukio AgoToshio Matsuda

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Citations

May 7, 2016·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toshio Matsuda
Jun 25, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ernest DalléMusa V Mabandla

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