"Role of the adipocyte hormone leptin in cardiovascular diseases - a study from Chennai based Population"

Thrombosis Journal
Devarajan NaliniRaghunathan Malathi

Abstract

Obesity is currently regarded as a pro-inflammatory condition during which leptin (Ob gene product) might act as a risk factor for Cardiovascular Diseases (CVD) including Acute Myocardial Infarction (AMI). There is a marked increase in circulating leptin concentrations and inflammatory markers such as Tumor Necrosis Factor-α (TNF-α) in AMI patients but still the association of leptin with inflammation during AMI is not known. The present study suggest that elevated levels of leptin might elicit the risk for CVD by signaling for the secretion of inflammatory cytokines especially, TNF-α. Blood samples were collected from 100 CVD subjects diagnosed for AMI immediately after their admission to the hospital and serum leptin, insulin, glucose, lipids and inflammatory marker such as TNF-α were measured. 5 ml random (non-fasting) blood was collected from 100 non-CVD (control) subjects and the results obtained in case of AMI subjects were compared with that of the control subjects. The subjects under study included both men and women belonging to the age group of 35 - 75 and they were classified based on their BMI as normal weight, overweight and obese. Circulating levels of leptin are found to be elevated in obese control subjects and ...Continue Reading

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Citations

Jul 28, 2016·Biochemical and Biophysical Research Communications·Nana LiWenyan Niu
Feb 14, 2019·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Silvia Helena de Carvalho Sales-PeresElinton Adami Chaim
Jan 26, 2021·Curēus·Asghar Hussain SyedBesham Kumar

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