Role of the aging vasculature and Erb B-2 signaling in epidermal growth factor-dependent intravasion of breast carcinoma cells

Cancer
Daniel J PriceHava Karsenty Avraham

Abstract

The risks for developing breast carcinoma and dying from the disease increase with age. Mortality from breast carcinoma usually is due to metastatic disease. Metastatic cells are able to invade into the vascular tissue in a growth factor-dependent manner. Because breast carcinoma mortality increases with age, examination of breast carcinoma interactions with young and aged endothelial cells is essential. We studied a series of breast epithelial cells (HMT-3522 cells) that exhibited either noninvasive characteristics (S-1 cells) or epidermal growth factor (EGF)-dependent invasive characteristics (T4-2 cells). Increased invasion of HMT-3522 cells was observed across an aged rat brain microvascular endothelial cell (BMEC) monolayer that was isolated from aged rats (24 months) compared with young rats (age 1 month). This increased invasion was inhibited by the specific EGF receptor inhibitor, AG1478, and by the Erb B-2-specific inhibitor, AG825. To analyze further the contribution of Erb B-2 to the EGF-dependent invasion of HMT-3522 cells, T4-2 cells were treated with the Erb B-2-specific therapeutic antibody trastuzumab and with the specific inhibitor AG825 and were then assayed for invasion. Both inhibitors led to a significant d...Continue Reading

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Citations

Mar 25, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ya LiShangwei Li
May 27, 2006·Journal of Gastroenterology and Hepatology·Prue M Pereira, Julie E Bines
Aug 19, 2009·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyungsun Choi, Chulhee Choi
Jan 13, 2011·Inhalation Toxicology·J Gregory MareshRalph V Shohet
Apr 30, 2021·Expert Review of Proteomics·Noemi ZorzettiAugusto Lauro

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