Role of the alpha-adducin genotype on renal disease progression

Kidney International
Jérôme NicodP Ferrari

Abstract

A genetic susceptibility to hypertension may predispose to the development of end-stage renal disease (ESRD) and promote a more rapid loss of renal function in patients with renal diseases. The alpha-adducin (ADD) gene, alone or in combination with the angiotensinogen (AGT) and the angiotensin-converting enzyme (ACE), is a candidate for abnormal blood pressure regulation and thus for increased susceptibility or faster progression to ESRD. Genotyping for the G460W-ADD, M235T-AGT and the insertion/deletion (I/D)-ACE gene polymorphisms was performed in 260 control subjects and 260 ESRD patients using polymerase chain reaction, gel analysis and appropriate restriction digest. The frequencies of the ADD, AGT and ACE genotypes in ESRD patients did not differ from observed frequencies in control subjects. The average (+/-SE) time from diagnosis to the onset of ESRD tended to be shorter in the presence of the ADD-460WW (5.1 +/- 1.1 years, N = 10) than with the GW (9.9 +/- 0.7 years, N = 81) and GG (11.3 +/- 1.0 years, N = 164) genotypes (F-ratio=2.71, P = 0.068; WW vs. GW P < 0.06 and vs. GG <0.03). In the 167 patients homozygous for the ADD-G allele, a more rapid progression with the ACE-DD genotype as compared to ACE-DI and II was fo...Continue Reading

References

Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Aug 1, 1991·American Journal of Medical Genetics·M J KhouryB H Cohen
Feb 1, 1989·Kidney International·P C BrazyJ F Fitzwilliam
Jul 23, 1987·Nature·K Gardner, V Bennett
Jan 4, 1996·The New England Journal of Medicine·M J KlagJ Stamler
Aug 11, 1995·The Journal of Biological Chemistry·C A Hughes, V Bennett
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·G BianchiM Ferrandi
Mar 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F LocatelliA Giangrande
Dec 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V M BuckalewG Schulman
Mar 6, 1998·Journal of Hypertension·M CastellanoE Agabiti-Rosei
May 15, 1998·Hypertension Research : Official Journal of the Japanese Society of Hypertension·S TamakiM Kinoshita
May 20, 1998·The American Journal of Cardiology·Z A AbbudJ B Kostis
Dec 10, 1999·Journal of the American Society of Nephrology : JASN·S PradervandB C Rossier
Jul 6, 2000·Journal of Human Hypertension·B Keavney
Jul 27, 2000·American Journal of Hypertension·M S BrayE Boerwinkle
Jan 6, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C Zoccali

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Citations

Sep 3, 2003·Biochemical and Biophysical Research Communications·Lorena CitterioCristina Barlassina
Jul 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Alessandra ZulianVera A Golovina
Dec 12, 2012·American Journal of Physiology. Renal Physiology·Marilyn BurkeRichard J Roman
Mar 11, 2009·PloS One·Cynthia Cooper WorobeyGary C Curhan
Oct 20, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mara FerrandiGiuseppe Bianchi
Mar 21, 2003·Biochemical and Biophysical Research Communications·Grazia TripodiGiuseppe Bianchi
Jun 5, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiaoyang LiaoYi Lei
May 14, 2004·American Journal of Physiology. Renal Physiology·Fatemeh FouladkouOlivier Staub
Aug 10, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Peter Karl Jacobsen
Feb 9, 2005·Hypertension·Giuseppe BianchiJan A Staessen
Aug 18, 2004·Hypertension·Giuseppe Bianchi, Paolo Manunta
Apr 14, 2006·Journal of Hypertension·Yoram Yagil, Chana Yagil
Feb 18, 2005·Journal of Hypertension·Chiara LanzaniPaolo Manunta
Jan 23, 2010·Journal of Hypertension·Fernando MartinezJosep Redon
Nov 10, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Giuseppe Bianchi
May 24, 2003·Annals of the New York Academy of Sciences·Giuseppe Bianchi, Grazia Tripodi
Dec 15, 2010·Journal of Hypertension·Kazuhiko SonoyamaAnthony M Heagerty
Jun 5, 2018·BioMed Research International·Karrie Mei-Yee Kiang, Gilberto Ka-Kit Leung

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