Role of the alpha v-integrin subunit in cell proliferation, apoptosis and tumor metastasis of laryngeal and hypopharyngeal squamous cell carcinomas: a clinical and in vitro investigation.

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Jian Guang LuMing Liu

Abstract

The objective of this study was to investigate the role of alpha v-integrin subunit (ITGAV, CD51) in invasion and metastasis of the laryngeal and hypopharyngeal squamous cell carcinomas and to evaluate whether an antisense oligonucleotide sequence (ASONs) targeting ITGAV gene can result in proliferative inhibition and induce to apoptosis of laryngeal carcinoma cell lines (Hep-2). Firstly, a tissue microarray contained 75 primary carcinomas, 29 non-cancerous normal tissues and 20 metastatic lymph nodes was constructed and used to detect the expression of ITGAV by immunohistochemistry. The changes of ITGAV expression from each group were assessed and correlated to the clinical parameters of the patients. Secondly, the ASONs targeting ITGAV gene was transfected into Hep-2 cells in vitro. The proliferative ability of the cells after transfection was measured by MTT assay and the apoptosis was detected using flow cytometry. Results showed that the expression of ITGAV was significantly correlated with differentiation and lymph node metastasis of these cancers. In vitro test showed that the proliferative ability of Hep-2 cells was significantly inhibited by ASONs in a way of concentration- and time-depending mode, and a significant ap...Continue Reading

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Citations

May 10, 2011·International Journal of Biological Sciences·Chengwen ChenYan Huang
Sep 5, 2014·Cell Death & Disease·L Planells-FerrerJ X Comella
Feb 12, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jing Ting WangJian Guang Lu
Jan 16, 2016·International Journal of Molecular Sciences·Roberta LottiCarlo Pincelli
Sep 15, 2017·Journal of Cell Communication and Signaling·Marion FlumKerstin Otte
May 5, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Changzhi WangMasao Iwamori
Apr 26, 2014·Frontiers in Oncology·Ala-Eddin Al MoustafaAmber Yasmeen
Jun 8, 2017·Cancers·Hanadi Talal AhmedahHelen M Sheldrake

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