Role of the angiopoietin/Tie system in pregnancy (Review)

Experimental and Therapeutic Medicine
D KappouD A Spandidos

Abstract

Angiopoietin-1 and -2 are endogenous ligands for the vascular endothelium-specific receptor tyrosine kinase Tie-2. The angiopoietin/Tie system plays a critical role in the regulation of endothelial cell survival and vascular maturation and stability. Apart from its well-established role in vascular morphogenesis, emerging data support the involvement of angiopoietins in inflammation and various malignancies. Previous studies have underlined the significance of several angiogenic factors in normal placental development. In addition, angiogenic imbalance is observed in pregnancy complications related to impaired placentation, such as preeclampsia (PE) and intrauterine growth restriction (IUGR). However, there is only limited information available on the role of the angiopoietin/Tie system in the establishment of a competent feto-maternal vascular system. In this review, we present the current knowledge regarding the role of angiopoietins in normal pregnancy and pregnancy complications.

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Citations

Sep 12, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vanesa HaukClaudia Pérez Leirós
Mar 7, 2019·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Mduduzi MazibukoThajasvarie Naicker
Mar 30, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gayatri RavikumarTirumalai Srinivas Sridhar
Jan 9, 2018·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Margarita L Martinez-FierroYolanda Ortiz-Castro
Jan 14, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gea BalleringRoel de Heus
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Jul 26, 2019·Current Hypertension Reports·Sayuri PadayacheeThajasvarie Naicker
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Jul 22, 2021·International Journal of General Medicine·Ebtisam Al-OfiNora Hakami

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