Role of the angiotensin II type 2 receptor in arterial remodeling after wire injury in mice

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Yoshiyuki YamamotoRyoji Ozono

Abstract

The angiotensin II type 2 (AT2) receptor promotes apoptosis and inhibits cell proliferation. In the present study, we investigated the role of the AT2 receptor in vascular repair and remodeling following severe vascular injury using AT2 knockout (AT2KO) mice. Left femoral arteries of AT2KO mice and wild-type (WT) control mice were injured by a 0.38 mm steel wire inserted from the lumen. Twenty-eight days after the injury, a concentric vascular wall thickening, composed largely of neointima, was noted both in AT2KO and WT mice. The area occupied by the neointima and the cell count within it were not different in the two mouse strains. However, the area of the medial layer and the cell count within it were significantly larger in AT2KO mice than in WT mice. A BrdU incorporation assay showed that the proliferative activity was high in the neointima but it was not different between the strains. On the other hand, apoptosis assessed by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) was significantly inhibited in the neointima and the media of AT2KO mice compared to the levels in WT mice. However, the number of TUNEL-positive cell was much smaller in the neointima than in the medial layer in both...Continue Reading

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Citations

Jul 22, 2009·European Journal of Pharmacology·Jacinthe LemayDenis deBlois
May 27, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naho KobayashiMitsuaki Isobe
Jun 29, 2012·Journal of Vascular Research·Naho KobayashiMitsuaki Isobe
Oct 29, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Catherine A Lemarié, Ernesto L Schiffrin
Apr 12, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wenxia SiQing Kenneth Wang
May 22, 2009·Expert Opinion on Therapeutic Patents·David W Laight
Jul 16, 2021·American Journal of Hypertension·Bernard I Lévy, Jean Jacques Mourad

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis