Role of the anterior thalamic nucleus in the motor hyperactivity induced by systemic MK-801 administration in rats

Neuropharmacology
Ximena López Hill, María Cecilia Scorza

Abstract

Non-competitive N-methyl-D-aspartate receptor (NMDA-R) antagonists have been extensively used in rodents to model psychotic symptoms of schizophrenia. Although the motor syndrome induced by acute and systemic administration of low doses of dizocilpine (MK-801) has been extensively characterized, its neurobiological basis is not fully understood. NMDA-R antagonists can disinhibit excitatory inputs in certain brain areas, but the precise circuitry is not fully known. We examined the involvement of the anterior thalamic nucleus (ATN) in hyperlocomotion and other related behaviors (stereotypies, ataxia signs) induced after acute systemic administration of MK-801. Since GABAergic neurons of the reticular thalamic nucleus (RTN) exert the main inhibitory control on thalamic projection neurons, we hypothesized that systemically injected MK-801 might block NMDA-R on RTN GABAergic neurons. This effect would subsequently result in disinhibition of GABAergic inputs onto ATN projections to cortical motor areas, thereby inducing behavioral effects. We evaluated the behavioral syndrome induced by the systemic administration MK-801 (0.2 mg/kg) in control rats and in rats subjected to a bilateral stereotaxic infusion of the GABA(A) agonist musc...Continue Reading

References

Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Oct 19, 1981·Brain Research·J M PalaciosM J Kuhar
Dec 1, 1995·Archives of General Psychiatry·J W Olney, N B Farber
Aug 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A C LahtiC A Tamminga
Feb 1, 1996·The American Journal of Psychiatry·M S BuchsbaumW E Bunney
Sep 1, 1996·Epilepsy Research·C KoernerM Vergnes
Sep 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A K MalhotraA Breier
Jan 1, 1996·Harvard Review of Psychiatry·J T Coyle
Jun 6, 2000·Biological Psychiatry·K A YoungD C German
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mark A Geyer, Bart Ellenbroek
Dec 4, 2003·Behavioural Brain Research·Harry B M UylingsBryan Kolb
Dec 20, 2003·Annals of the New York Academy of Sciences·Bita Moghaddam, Mark E Jackson
Aug 7, 2004·Brain Research. Brain Research Reviews·Didier Pinault
Sep 18, 2004·The British Journal of Surgery·N LabropoulosO Paxinos
Jan 28, 2005·Cellular and Molecular Neurobiology·Jussi VäisänenEero Castrén
Apr 10, 2007·Epilepsy & Behavior : E&B·Frank R Sharp, Robert L Hendren
Sep 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lucila KargiemanFrancesc Artigas
Feb 6, 2008·The International Journal of Neuropsychopharmacology·María Cecilia ScorzaFrancesc Artigas
Oct 24, 2008·Frontiers in Molecular Neuroscience·Colin KehrerTengis Gloveli
Apr 16, 2009·Neuroscience Research·Nicola G CascellaAkira Sawa
Jan 9, 2010·Frontiers in Neural Circuits·Yuchun ZhangJohn E Lisman

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