PMID: 7021651Jul 1, 1980Paper

Role of the autonomic nervous system in the mediation of LHA electrical stimulation-induced effects on insulinemia and glycemia

Journal of the Autonomic Nervous System
H R BerthoudB Jeanrenaud

Abstract

The short-term effects of bilateral electrical stimulation of the lateral component of the lateral hypothalamic/medial forebrain bundle area (LHA) on peripheral plasma levels of glucose (G), immunoreactive insulin (IRI) and glucagon (IRG) were measured in food-derived, anesthetized rats in the presence of continuous low i.v. glucose infusion. In normal rats LHA stimulation induced a rapid but moderate rise in IRI in the presence of a simultaneous rapid rise in G. At the end of the 5 min stimulation period the glucose-induced IRI response was clearly attenuated. In rats receiving a continuous phentolamine (i.v.) infusion, the rapid IRI response was much larger in spite of only marginal rises of G. These findings suggest that electrical LHA stimulation activates two opposing mechanisms on IRI secretion, an excitatory component which is masked in normal animal by a sympathetic alpha-adrenergic inhibitory component. In an attempt to define the mediating pathway of this LHA stimulation-induced IRI excitatory component, both the parasympathetic and sympathetic divisions of the autonomic nervous system were pharmacologically and surgically manipulated, all in the presence of phentolamine infusion. Neither bilateral subdiaphragmatic va...Continue Reading

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Citations

Oct 1, 1983·Journal of the Autonomic Nervous System·F Rohner-JeanrenaudB Jeanrenaud
Apr 1, 1984·Journal of the Autonomic Nervous System·B J Davis, P H Smith
Mar 1, 1984·Journal of the Autonomic Nervous System·P G LuitenA B Steffens
Jul 17, 2003·Brain Research·Chunhui JiangXueguo Zhang
Aug 17, 2011·Diabetes, Obesity & Metabolism·B Thorens
Jan 1, 1990·Annals of the New York Academy of Sciences·C V Grijalva, D Novin
Dec 18, 2013·The Journal of Clinical Investigation·David TarussioBernard Thorens
Jul 15, 2015·Trends in Endocrinology and Metabolism : TEM·Laura SteinbuschBernard Thorens
Jul 23, 2013·Organogenesis·Léa M M CostesCathy Cailotto
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Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P van den Bosch de Aguilar, J Goemaere-Vanneste
Feb 1, 1982·Journal of Neurosurgery·W BinkleyR Worth
Jun 9, 2019·Toxins·Letizia PolitoAndrea Bolognesi
Aug 1, 1985·Annals of Neurology·M TakatsuL Freddo
Oct 1, 1990·European Journal of Clinical Investigation·E Bobbioni-Harsch, B Jeanrenaud
Apr 1, 1983·The American Journal of Physiology·M CrettazB Jeanrenaud
Jul 1, 1981·The American Journal of Physiology·D A BereiterB Jeanrenaud
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger

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