PMID: 7333659Jan 1, 1981Paper

Role of the B-G-region antigen in the humoral immune response to the B-F-region antigen of chicken MHC

Immunogenetics
K HálaJ Schulmannová

Abstract

In the chicken MHC there exist two regions, designated F and G, which were separated by crossing-over. The F region contains genes controlling all functions characteristic of the MHC. So far only one gene has been assigned to the G region and it is responsible for the presence of an RBC antigen. When cross-immunizing animals of the congenic lines CB and CC with erythrocytes, we have found that both F- and G-specific antibodies were produced. By using the recombinant haplotypes Br1 and Br2 we were able to dissociate the F from the G antigen and immunize with them separately. It was found that production of F antibodies required the copresence of the G antigen, whereas G antibodies were formed regardless of the presence of absence of the F-region antigen. It could be demonstrated that a prerequisite of the role of the G antigen with respect to the F antigen was the localization of both antigens on the same erythrocyte. Possible mechanisms underlying this phenomenon are discussed.

References

Jan 1, 1977·Advances in Experimental Medicine and Biology·K HálaJ Hartmanová
Jan 1, 1977·Advances in Experimental Medicine and Biology·M SimonsenM Vilhelmová
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·P Lake, N A Mitchison
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·G Möller
Jan 1, 1971·Transplantation·J H Stimpfling, C R McBroom
Sep 11, 1970·Science·P Bretscher, M Cohn
May 5, 1967·Science·L W Schierman, R A McBride
Jan 1, 1980·Immunogenetics·M SimonsenE M Nicolaisen

❮ Previous
Next ❯

Citations

Jan 1, 1990·Immunologic Research·G KroemerC Auffray
Jan 1, 1990·Developmental and Comparative Immunology·T J MorganK Kline
Dec 1, 1993·Veterinary Immunology and Immunopathology·M H Pinard, B G Hepkema
Jan 1, 1992·Immunology Today·J Kaufman, J Salomonsen
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J KaufmanD Thorpe
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M M MillerC G Miyada
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J SalomonsenJ Kaufman
Jan 1, 1987·Avian Pathology : Journal of the W.V.P.A·B M Freeman, N Bumstead
Feb 1, 1990·Immunological Reviews·J KaufmanJ Salomonsen
Dec 1, 1981·Scandinavian Journal of Immunology·K HálaG Wick
Feb 1, 1983·Tissue Antigens·C KochP Toivanen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.