PMID: 9525662Apr 3, 1998Paper

Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia

Journal of Virology
A GhorpadeC R Mackay

Abstract

Human immunodeficiency virus type 1 (HIV-1) infection in mononuclear phagocyte lineage cells (monocytes, macrophages, and microglia) is a critical component in the pathogenesis of viral infection. Viral replication in macrophages serves as a reservoir, a site of dissemination, and an instigator for neurological sequelae during HIV-1 disease. Recent studies demonstrated that chemokine receptors are necessary coreceptors for HIV-1 entry which determine viral tropism for different cell types. To investigate the relative contribution of the beta-chemokine receptors CCR3 and CCR5 to viral infection of mononuclear phagocytes we utilized a panel of macrophage-tropic HIV-1 strains (from blood and brain tissue) to infect highly purified populations of monocytes and microglia. Antibodies to CD4 (OKT4A) abrogated HIV-1 infection. The beta chemokines and antibodies to CCR3 failed to affect viral infection of both macrophage cell types. Antibodies to CCR5 (3A9) prevented monocyte infection but only slowed HIV replication in microglia. Thus, CCR5, not CCR3, is an essential receptor for HIV-1 infection of monocytes. Microglia express both CCR5 and CCR3, but antibodies to them fail to inhibit viral entry, suggesting the presence of other chemo...Continue Reading

References

Jul 10, 1986·Nature·A T Haase
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W S PearD Baltimore
Sep 1, 1994·Journal of Leukocyte Biology·H E GendelmanH S Nottet
Aug 29, 1996·Nature·H SchmidtmayerovaM Bukrinsky
Feb 17, 1997·The Journal of Experimental Medicine·R I ConnorN R Landau
Mar 3, 1997·The Journal of Experimental Medicine·A SicaA Mantovani

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Citations

Nov 30, 2000·Current Infectious Disease Reports·D B Clifford
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Uriel HazanFrance Pietri-Rouxel
Jul 26, 2002·International Journal of Hematology·Kiyoko S Akagawa
Nov 25, 2003·Clinical and Experimental Immunology·C Farquhar, G John-Stewart
Oct 19, 2004·Clinical Microbiology Reviews·R Bryan RockPhillip K Peterson
Jan 13, 2012·Protein Engineering, Design & Selection : PEDS·Yingping WuWenyan Wu
Sep 12, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Frances ZenónLoyda M Meléndez
Jun 21, 2015·Journal of Neurovirology·Frances ZenónLoyda M Melendez
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J A BelperioR M Strieter
Oct 24, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Eric AndersonHoward E Gendelman
Jan 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kiyoko S AkagawaFumio Kishi
Sep 10, 2002·AIDS·Julio Martín-GarcíaFrancisco González-Scarano
Jun 25, 1999·AIDS Research and Human Retroviruses·P ShapshakK Goodkin
Dec 22, 1999·AIDS Research and Human Retroviruses·Y L HongF Z Chung
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·M BabaM Fujino
Feb 7, 2009·Stem Cells and Development·Malgorzata Simm
Feb 26, 2000·Annual Review of Genetics·H TangF Wong-Staal
May 31, 2002·AIDS Research and Human Retroviruses·Georgette D KanmognePaula Grammas
May 28, 2004·Journal of Virology·Michael D BobardtPhilippe A Gallay
Aug 13, 1999·AIDS Research and Human Retroviruses·S HibbittsP R Clapham
Nov 5, 2003·Journal of Leukocyte Biology·Yuri Persidsky, Howard E Gendelman
Jul 10, 1999·Journal of Virology·S W DowE A Hoover

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