PMID: 2115069Aug 1, 1990Paper

Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors

Journal of Neurochemistry
S A MooreA A Spector

Abstract

Elongated, more highly polyunsaturated derivatives of linoleic acid (18:2 omega-6) and linolenic acid (18:3 omega-3) accumulate in brain, but their sites of synthesis and mechanism of entry are not well characterized. To investigate the role of the blood-brain barrier in this process, cultured murine cerebromicrovascular endothelia were incubated with [1-14C]18:2 omega-6 or [1-14C]18:3 omega-3 and their elongation/desaturation products determined. The major metabolite of 18:2 omega-6 was 20:4 omega-6, whereas the primary product from 18:3 omega-3 was 20:5 omega-3. Although these products were found primarily in cell lipids, they were also released from the cells and gradually accumulated in the extracellular fluid. Eicosanoid production was observed from the 20:4 omega-6 and 20:5 omega-3 that were formed. No 22:5 omega-6 or 22:6 omega-3 fatty acids were detected, suggesting that these endothelial cells are not the site of the final desaturation step. Although the uptake of 18:3 omega-3 and 18:2 omega-6 was nearly identical, 18:3 omega-3 was more extensively elongated and desaturated. Competition experiments demonstrated a preference for 18:3 omega-3 by the elongation/desaturation pathway. These findings suggest that the blood-b...Continue Reading

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P NeedlemanH Sprecher
Apr 1, 1978·Journal of Neurochemistry·S R Cohen, J Bernsohn
Aug 1, 1989·Journal of Neurochemistry·S A MooreM N Hart
May 15, 1986·The Biochemical Journal·D T Dudley, A A Spector
Jan 1, 1987·Progress in Lipid Research·M D Rosenthal
Feb 1, 1988·Journal of Neurochemistry·R Spector
Jan 1, 1988·The American Journal of Physiology·S A MooreM N Hart
Apr 1, 1988·Lipids·G J Anderson, W E Connor
Apr 13, 1987·Life Sciences·H Schulz
Jan 1, 1973·Advances in Lipid Research·G A Dhopeshwarkar, J F Mead
Jul 13, 1971·Biochimica Et Biophysica Acta·G A DhopeshwarkarJ F Mead
Feb 2, 1971·Biochimica Et Biophysica Acta·G A DhopeshwarkarJ F Mead
Nov 1, 1982·Journal of Cellular Physiology·M D Rosenthal, M C Whitehurst
Oct 1, 1981·The Journal of Clinical Investigation·A A SpectorG L Fry
Jan 1, 1980·Progress in Lipid Research·W K YamanakaM L Hutchinson
Jan 1, 1982·Pharmacology & Therapeutics·R P White, A A Hagen
Jan 1, 1980·Progress in Lipid Research·A A SpectorB T Hyman
Jul 1, 1981·Journal of Neurochemistry·B T Hyman, A A Spector

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Citations

Jan 1, 1994·Lipids·R T HolmanJ W Crofts
Aug 1, 1995·Progress in Neurobiology·H Katsuki, S Okuda
Sep 1, 1996·Journal of Lipid Mediators and Cell Signalling·A PetroniC Galli
Nov 26, 1998·Progress in Lipid Research·D R TocherP A Hodgson
Oct 23, 2002·Journal of Neurochemistry·Elena B Rodriguez de TurcoMyron D Ginsberg
May 16, 2001·Current Opinion in Lipidology·U Beisiegel, A A Spector
Jul 9, 2010·Journal of Lipid Research·Monika RiedererSasa Frank
May 24, 2003·In Vitro Cellular & Developmental Biology. Animal·Stefanie D KrämerDavid J Begley
Aug 14, 1997·Annals of the New York Academy of Sciences·C Y HsuJ Xu
Feb 6, 2008·Journal of Neurochemistry·Terry L KaduceArthur A Spector
Sep 1, 2015·Neurochemistry International·Kusumika GharamiSumantra Das
Jul 22, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Marina Mandelsamen Perica, Ivancica Delas
Jul 1, 1992·Journal of Neurochemistry·R E Martin, N G Bazan
Jun 25, 2009·Developmental Medicine and Child Neurology·Raanan Raz, Lidia Gabis
Oct 9, 2014·Journal of Neural Transmission·Shlomo Yehuda, Sharon Rabinovitz
Dec 13, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anniek WernerHenkjan J Verkade
May 10, 2007·The Journal of Biological Chemistry·Hee-Yong Kim
Jun 22, 1999·Journal of Neuroscience Research·S YehudaD I Mostofsky
Jun 18, 1997·Biochemical and Biophysical Research Communications·J XuC Y Hsu

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