Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.

Bioorganic & Medicinal Chemistry Letters
Gary E KeckPeter M Blumberg

Abstract

The role of the C(8) gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562, and MV4-11 cells as well as the profiles for downregulation of PKC isozymes revealed that the presence of this group is not a critical determinant for the unique pattern of biological activity of bryostatin.

Citations

Dec 30, 2015·Marine Drugs·Patrizia RussoMassimo Fini
Feb 10, 2016·Molecular Carcinogenesis·Jessica S KelseyPeter M Blumberg
Aug 6, 2016·The Journal of Organic Chemistry·David O BaumannGary E Keck
Mar 29, 2014·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Kazuhiro Irie, Ryo C Yanagita
Mar 9, 2017·Organic & Biomolecular Chemistry·Raphaël DumeunierEric J Thomas
Mar 9, 2017·Organic & Biomolecular Chemistry·Matthew BallEric J Thomas
Feb 10, 2018·Chembiochem : a European Journal of Chemical Biology·Thomas J CumminsGary E Keck
Oct 8, 2016·Organic & Biomolecular Chemistry·Matthew BallEric J Thomas
Nov 8, 2017·Organic & Biomolecular Chemistry·Anthony P GreenEric J Thomas
Nov 8, 2017·Organic & Biomolecular Chemistry·Anthony P GreenEric J Thomas
Mar 9, 2018·Chembiochem : a European Journal of Chemical Biology·Xiguang ZhaoPeter M Blumberg
Jan 27, 2019·Organic & Biomolecular Chemistry·Paul R MearsEric J Thomas
Sep 11, 2014·Journal of the American Chemical Society·Matthew B KraftGary E Keck

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