PMID: 18719736Aug 23, 2008Paper

Role of the caudal pressor area in the regulation of sympathetic vasomotor tone

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
R R CamposC T Bergamaschi

Abstract

It is well known that the ventrolateral medulla contains neurons involved in the tonic and reflex control of the cardiovascular system. Two regions within the ventrolateral medulla were initially identified: the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM). Activation of the RVLM raises arterial blood pressure and sympathetic nerve activity, and activation of the CVLM causes opposite effects. The RVLM premotor neurons project directly to sympathetic preganglionic neurons and are involved in the maintenance of resting sympathetic vasomotor tone. A significant proportion of tonic activity in the RVLM sympathetic premotor neurons is driven by neurons located in a third region of the ventrolateral medulla denominated caudal pressor area (CPA). The CPA is a pressor region located at the extreme caudal part of the ventrolateral medulla that appears to have an important role controlling the activity of RVLM neurons. In this brief review, we will address the importance of the ventrolateral medulla neurons for the generation of resting sympathetic tone related to arterial blood pressure control focusing on two regions, the RVLM and the CPA.

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Citations

Dec 1, 2006·Experimental Brain Research·Masoumeh Hatam, Ali Nasimi
Jun 30, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Mohammad Naser ShafeiMahmoud Hosseini
Jun 25, 2009·Journal of Chemical Neuroanatomy·Ann K Goodchild, Elizabeth A Moon
Apr 14, 2015·Journal of Neuroscience Methods·Xianglong LiY James Kang
Jul 8, 2010·Hypertension·Elizabeth B Oliveira-SalesJulian F R Paton
Nov 2, 2017·Neural Regeneration Research·Hisham Sharif, Shaoping Hou

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