Role of the Choroid in Age-related Macular Degeneration: A Current Review

Journal of Ophthalmic & Vision Research
Marybeth K Farazdaghi, Katayoon B Ebrahimi

Abstract

Age-related macular degeneration (AMD) is a major cause of vision loss in the developed world and its pathogenesis is a topic of active research. To date, much study has been focused on the role of the retinal pigment epithelium (RPE) and Bruch's membrane (BrM) in AMD pathogenesis, but the role of the choroid has also been investigated. In this review, we focus on recent advancements in research in the role of the choroid in AMD, beginning with an exploration of the histopathologic, cellular and molecular changes that occur in the choroid in AMD and concluding by discussing new choroidal imaging techniques and patterns seen on fluorescein angiography, indocyanine green angiography, spectral-domain optical coherence tomography and optical coherence tomography angiography. Exploring these domains will lead to a better understanding of the factors at play beyond the outer retina in this important disease.

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Citations

Feb 27, 2020·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Thomas J HeesterbeekAnneke I den Hollander
Mar 11, 2020·Expert Opinion on Pharmacotherapy·Daniele VerittiPaolo Lanzetta
Feb 3, 2021·International Journal of Molecular Sciences·Yue RuanAdrian Gericke
Jan 29, 2021·Frontiers in Cell and Developmental Biology·Tu NguyenRaymond Ching-Bong Wong
Apr 27, 2021·Investigative Ophthalmology & Visual Science·Elzbieta KrytkowskaAnna Machalinska
Jul 25, 2021·Scientific Reports·Elżbieta KrytkowskaAnna Machalińska
Aug 21, 2021·Klinische Monatsblätter für Augenheilkunde·Teresa Barth, Horst Helbig
Nov 18, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Michael Landowski, Catherine Bowes Rickman

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Methods Mentioned

BETA
imaging techniques

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