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Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo

Molecular and Cellular Biology

Dec 28, 1999

S M LuohFrederic J de Sauvage

PMID: 10611229

Abstract

The cytokine thrombopoietin (TPO) controls the formation of megakaryocytes and platelets from hematopoietic stem cells. TPO exerts its effect through activation of the c-Mpl receptor and of multiple downstream signal transduction pathways. While the membrane-proximal half of the cytopla...read more

Mentioned in this Paper

Biochemical Pathway
Exertion
Colony-Forming Units, Hematopoietic
Carboxy-Terminal Amino Acid
Mitogen-Activated Protein Kinases
Megakaryocytes
Amino Acids, I.V. solution additive
Protoplasm
Thrombopoiesis
MPL wt Allele
13
Paper Details
References
  • References18
  • Citations38
12
  • References18
  • Citations38
1234

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Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain

Proceedings of the National Academy of Sciences of the United States of AmericaMarch 18, 1997
Jonathan G Drachman, Kenneth Kaushansky
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Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo

Molecular and Cellular Biology

Dec 28, 1999

S M LuohFrederic J de Sauvage

PMID: 10611229

DOI:

Abstract

The cytokine thrombopoietin (TPO) controls the formation of megakaryocytes and platelets from hematopoietic stem cells. TPO exerts its effect through activation of the c-Mpl receptor and of multiple downstream signal transduction pathways. While the membrane-proximal half of the cytopla...read more

Mentioned in this Paper

Biochemical Pathway
Exertion
Colony-Forming Units, Hematopoietic
Carboxy-Terminal Amino Acid
Mitogen-Activated Protein Kinases
Megakaryocytes
Amino Acids, I.V. solution additive
Protoplasm
Thrombopoiesis
MPL wt Allele
13

Feeds With Similar Papers

Hematopoiesis In Aging

Hematopoiesis is the process by which a limited number of hematopoietic stem cells maintain a functioning blood and immune system. Aging of these stem cells leads to several functional changes, including alterations affecting self-renewal and differentiation. Here is the latest research.

Hematopoetic Stem Cells

Hematopoietic stem cells (HSCs) are the cells that give rise to blood cells of the myeloid and lymphoid lineage during hematopoiesis. HSC transplantation is an established therapeutic option for both malignant and nonmalignant indications. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain

Proceedings of the National Academy of Sciences of the United States of AmericaMarch 18, 1997
Jonathan G Drachman, Kenneth Kaushansky
Science

Thrombocytopenia in c-mpl-deficient mice

ScienceSeptember 2, 1994
A L GurneyM W Moore
Paper Details
References
  • References18
  • Citations38
12
  • References18
  • Citations38
1234

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