PMID: 1195561Nov 1, 1975Paper

Role of the disulfide bridge and the C-terminal tripeptide in the antidiuretic action of vasopressin in man and the rat

Kidney International
J H CortJ L Mulder

Abstract

The antidiuretic action of a number of vasopressin analogues has been measured in the rat and man in water diuresis. These analogues had the following categories of structural alteration: a) substitution of -CH2CH2-(dicarba) and -SCH2-(6-monocarba) for the natural -SS- bridge between residues 1 and 6, b) changes in the nature of the C-terminal tripeptide produced by substitution of D-arginine and L-Nalpha-methylarginine for L-arginine in sequence position 8 and L-leucine for proline in position 7, and c) combinations of a and b. In addition, a highly active analogue which results when valine is substituted for glutamine in position 4 was tested. Trained, unanesthetized rats and normal human volunteers were complemented by a volunteer patient with posttraumatic diabetes insipidus (DI) in the total group of experimental subjects. The only change in the C-terminal tripeptide which was associated with a high antidiuretic action was D-Arg substitution. The meArg and Leu analogues showed low to very little activity and no signs of antidiuretic antagonist action. All of the carba analogues showed both high potency and prolongation of antidiuretic action in the following order (for both potency and duration): monocarba + 8-D-Arg greate...Continue Reading

References

Mar 1, 1971·Endocrinology·M KoidaR Walter
Jan 1, 1974·European Journal of Pharmacology·T BarthI Rychlík
Aug 18, 1973·British Medical Journal·C R EdwardsG M Besser
Jan 1, 1974·Advances in Protein Chemistry·B Pullman, A Pullman
Feb 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·N MarksR Walter
Mar 1, 1973·Acta paediatrica Scandinavica·A S AronsonJ L Mulder
May 1, 1967·The American Journal of Medicine·H D Lauson
Oct 1, 1960·The Journal of Urology·A R KENDALL
Sep 1, 1948·The Journal of Clinical Investigation·J Brod, J H Sirota

❮ Previous
Next ❯

Citations

Oct 18, 1978·Pflügers Archiv : European journal of physiology·A KonradsF Gross
May 1, 1981·Molecular and Cellular Endocrinology·W H SawyerM Manning
Sep 15, 1998·Kidney International. Supplement·J SchnermannJ P Briggs
Aug 12, 1976·The New England Journal of Medicine
Jan 1, 1982·Journal of Immunoassay·P Rooke, P H Baylis
Dec 1, 1988·Clinical and Experimental Pharmacology & Physiology·M P RechtmanA L Boura
Aug 1, 2002·Journal of Peptide Science : an Official Publication of the European Peptide Society·Sylwia Rodziewicz-MotowidłoJacek Wójcik
Mar 28, 2013·Journal of Peptide Science : an Official Publication of the European Peptide Society·Anna V KutinaYuri V Natochin
Jul 10, 2013·Regulatory Peptides·Anna V KutinaYury V Natochin
Jan 19, 2007·Journal of Mass Spectrometry : JMS·M Reid GrosecloseRichard M Caprioli
Oct 1, 1986·International Journal of Peptide and Protein Research·M L MooreJ McDonald
May 17, 2008·Molecular Pharmaceutics·Weiqiang Cheng, Lee-Yong Lim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.