PMID: 11898801Mar 20, 2002Paper

Role of the dorsomedial striatum in behavioral flexibility for response and visual cue discrimination learning

Behavioral Neuroscience
M E RagozzinoR P Kesner

Abstract

These experiments examined the effects of dorsomedial striatal inactivation on the acquisition of a response and visual cue discrimination task, as well as a shift from a response to a visual cue discrimination, and vice versa. In Experiment 1, rats were tested on the response discrimination task followed by the visual cue discrimination task. In Experiment 2, the testing order was reversed. Infusions of 2% tetracaine did not impair acquisition of the response or visual cue discrimination but impaired performance when shifting from a response to a visual cue discrimination, and vice versa. Analysis of the errors revealed that the deficit was not due to perseveration of the previously learned strategy, but to an inability to maintain the new strategy. These results contrast with findings indicating that prelimbic inactivation impairs behavioral flexibility due to perseveration of a previously learned strategy. Thus, specific circuits in the prefrontal cortex and striatum may interact to enable behavioral flexibility, but each region may contribute to distinct processes that facilitate strategy switching.

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Citations

Feb 12, 2013·Behavioural Brain Research·Zsuzsanna Callaerts-VeghRudi D'Hooge
Oct 3, 2003·Neurobiology of Learning and Memory·Michael E Ragozzino
Jan 30, 2004·Learning & Memory·Michael E Ragozzino, Daniel Choi
Aug 25, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark R Stefani, Bita Moghaddam
Feb 27, 2008·Behavioral Neuroscience·Andrea M BrushfieldPaul E Gilbert
Jun 3, 2008·Behavioral Neuroscience·Charles L Pickens
Jul 30, 2008·The Behavioral and Brain Sciences·A David RedishAdam Johnson
Oct 24, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hannah F ClarkeAngela C Roberts
Jan 16, 2009·Journal of Neurophysiology·Joshua D BerkeHoward Eichenbaum
Mar 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eyal Yaacov Kimchi, Mark Laubach
Apr 2, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bjoern Lex, Wolfgang Hauber
Sep 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stan B Floresco, James D Jentsch
Oct 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Holden D BrownMichael E Ragozzino
Apr 20, 2011·Behavioral Neuroscience·Amy C ChessJohn T Green
Dec 3, 2011·The Journal of Pharmacology and Experimental Therapeutics·Michael E RagozzinoWilliam S Messer
Apr 27, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ryan M BastleJanet L Neisewander
Jun 13, 2012·Physiology·Alexxai V Kravitz, Anatol C Kreitzer
Jul 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Satoshi YawataShigetada Nakanishi
Apr 20, 2014·Brain Research Bulletin·Natalia AriasJorge L Arias
Dec 23, 2003·The European Journal of Neuroscience·Michelle M Nicolle, Mark G Baxter
Jun 28, 2019·Frontiers in Behavioral Neuroscience·Szabolcs BiróThomas Klausberger

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