Role of the duodenum in regulation of plasma ghrelin levels and body mass index after subtotal gastrectomy.

World Journal of Gastroenterology : WJG
Hai-Tao WangHai-Xin Qian

Abstract

To investigate the role of the duodenum in the regulation of plasma ghrelin levels and body mass index (BMI), and the correlation between them after subtotal gastrectomy. Forty-two patients with T0-1N0-1M0 gastric cancer were divided into two groups after gastrectomy according to digestive reconstruction pattern, Billroth I group (n = 23) and Billroth II group (n = 19). Ghrelin levels were determined with radioimmunoassay (RIA) before and on d 1, 7, 30 and 360 after gastrectomy, and BMI was also measured. The two groups had identical postoperative trends in ghrelin alterations during the early stage, both decreasing sharply to a nadir on d 1 (36.7% vs 35.7%), then markedly increasing on d 7 (51.0% vs 51.1%). On d 30, ghrelin levels in the Billroth I group were slightly higher than those in the Billroth II group. However, those of the Billroth I group recovered to 93.6% on d 360, which approached, although lower than, the preoperative levels, and no statistically significant difference was observed. Those of the Billroth II group recovered to only 81.6% and manifested significant discrepancy with preoperative levels (P = 0.033). Compared with preoperative levels, ghrelin levels of the two groups decreased by 6.9% and 18.4% and B...Continue Reading

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Citations

Dec 8, 2010·Surgical Endoscopy·Kyu-Chul KangUNKNOWN Korean Laparoscopic Gastrointestinal Surgery Study (KLASS) Group
Jan 26, 2011·Current Treatment Options in Oncology·Amelia BakerMichele Malloy
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Apr 19, 2015·Lipids in Health and Disease·Jin Won LeeKyo Young Song
Dec 31, 2016·International Journal of Molecular Sciences·Conor F Murphy, Carel W le Roux
Jun 3, 2021·Children·Valeria CalcaterraFatima Cody Stanford

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