Role of the endocannabinoid system in the mechanisms involved in the LPS-induced preterm labor

Reproduction : the Official Journal of the Society for the Study of Fertility
María Victoria BarianiJ Aisemberg

Abstract

Prematurity is the leading cause of perinatal morbidity and mortality worldwide. There is a strong causal relationship between infection and preterm births. Intrauterine infection elicits an immune response involving the release of inflammatory mediators like cytokines and prostaglandins (PG) that trigger uterine contractions and parturition events. Anandamide (AEA) is an endogenous ligand for the cannabinoid receptors CB1 and CB2. Similarly to PG, endocannabinoids are implicated in different aspects of reproduction, such as maintenance of pregnancy and parturition. Little is known about the involvement of endocannabinoids on the onset of labor in an infectious milieu. Here, using a mouse model of preterm labor induced by lipopolysaccharide (LPS), we explored changes on the expression of components of endocannabinoid system (ECS). We have also determined whether AEA and CB antagonists alter PG production that induces labor. We observed an increase in uterine N-acylphosphatidylethanolamine-specific phospholipase D expression (NAPE-PLD, the enzyme that synthesizes AEA) upon LPS treatment. Activity of catabolic enzyme fatty acid amide hydrolase (FAAH) did not change significantly. In addition, we also found that LPS modulated uter...Continue Reading

References

Jan 1, 1987·Methods in Enzymology·W B Campbell, S R Ojeda
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·B C PariaS K Dey
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·P C SchmidS K Dey
Aug 26, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K VargaG Kunos
Nov 5, 1999·Methods in Molecular Biology·S Rozen, H Skaletsky
Jun 6, 2000·Trends in Pharmacological Sciences·D PiomelliF Rodríguez de Fonseca
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G GrossL J Muglia
Oct 12, 2001·Annals of the New York Academy of Sciences·J R ChallisN Alfaidy
Dec 31, 2002·Chemistry and Physics of Lipids·Herbert SchuelAndrea Giuffrida
Sep 10, 2003·Journal of Leukocyte Biology·Thomas W KleinHerman Friedman
Jan 30, 2004·American Journal of Obstetrics and Gynecology·Michael C DennedyJohn J Morrison
Aug 6, 2004·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·N LazzarinM Maccarrone
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Osama M H HabayebJustin C Konje
Aug 4, 2006·The Journal of Clinical Investigation·Haibin WangSudhansu K Dey
Jan 30, 2007·Prostaglandins & Other Lipid Mediators·D P Mishra, A Dhali
Jun 23, 2007·Human Reproduction Update·A H TaylorJ C Konje
Nov 29, 2007·American Journal of Physiology. Endocrinology and Metabolism·Murray D MitchellMichelle Glass
Oct 4, 2008·PloS One·Haibin WangSudhansu K Dey
Feb 25, 2009·PloS One·Mona R El-TalatiniJustin C Konje
Mar 14, 2009·Molecular Endocrinology·Carole R Mendelson
Jul 16, 2009·Progress in Lipid Research·Mauro Maccarrone
Feb 6, 2010·Neuroimmunomodulation·Julieta AisembergAna María Franchi
Feb 8, 2011·Progress in Lipid Research·P Pacher, R Mechoulam
Dec 5, 2012·Journal of Cellular and Molecular Medicine·Oksana ShynlovaStephen J Lye
Dec 10, 2013·Journal of Pineal Research·Ana Paula Domínguez RubioAna María Franchi
Jul 23, 2014·Endocrinology·Xiaofei SunSudhansu K Dey

❮ Previous
Next ❯

Citations

Nov 16, 2017·American Journal of Physiology. Endocrinology and Metabolism·Kushal GandhiNatalia Schlabritz-Loutsevitch
Jul 19, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lin FuDe-Xiang Xu
Aug 16, 2017·Molecular Human Reproduction·María Victoria BarianiAna María Franchi
Aug 29, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Erica Zamberletti, Tiziana Rubino
Jun 8, 2021·Frontiers in Physiology·Paula AccialiniMariana Farina
Jul 6, 2021·Frontiers in Endocrinology·Melissa L KozakiewiczAllyn C Howlett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.