PMID: 6165739Jun 1, 1981Paper

Role of the endogenous kallikrein-kinin system in modulating vasopressin-stimulated water flow and urea permeability in the toad urinary bladder

The Journal of Clinical Investigation
C P CarvounisL A Arbeit

Abstract

This study investigates the endogenous kallikrein-kinin system's role as a modulator of vasopressin action in the toad urinary bladder. Kalli-krein inhibition by aprotinin, which results in decreased kinin production, significantly increased both vasopressin and 8-Br-cyclic (c) AMP-stimulated water flow. Kinin potentiation by the kininase II inhibitor captopril (SQ 14225) significantly decreased vasopressin and 8-Br-cAMP-stimulated water flow. In contrast to water flow, vasopressin-stimulated urea permeability was decreased by aprotinin and increased by captopril. We conclude that the endogenous kallikrein-kinin system represents a significant modulator of vasopressin action and it permits separate control of vasopressin-stimulated water flow and solute transport.

References

May 1, 1979·Kidney International·C P CarvounisR M Hays
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Citations

Jan 1, 1984·The Journal of Membrane Biology·W A Kachadorian, J Muller
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·G G Orce, G A Castillo
Mar 1, 1984·The Journal of Clinical Investigation·M L KaukerA Nasjletti
Jun 1, 1984·The Journal of Clinical Investigation·V L SchusterH R Jacobson
Mar 1, 1985·Kidney International·G CarvounisL A Arbeit
May 1, 1987·Kidney International·M L KaukerA Nasjletti
May 1, 1986·Kidney International·P J Fuller, J W Funder
Aug 1, 1985·Kidney International·P E KlotmanW E Yarger
Dec 18, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Paleerath PeerapenVisith Thongboonkerd
Sep 4, 1999·Clinical and Experimental Pharmacology & Physiology·Y MatsumuraT Yamasaki
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R M Pérez-AyusoJ Rodés
Jun 23, 2000·Journal of the American Society of Nephrology : JASN·Joost P SchanstraBenoit Jeunier
Aug 25, 1986·The American Journal of Medicine·D Schlondorff
Jun 1, 1987·Kidney International·V J Dzau

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