Role of the ERK pathway in psychostimulant-induced locomotor sensitization

BMC Neuroscience
Emmanuel ValjentDenis Hervé

Abstract

Repeated exposure to psychostimulants results in a progressive and long-lasting facilitation of the locomotor response that is thought to have implications for addiction. Psychostimulants and other drugs of abuse activate in specific brain areas extracellular signal-regulated kinase (ERK), an essential component of a signaling pathway involved in synaptic plasticity and long-term effects of drugs of abuse. Here we have investigated the role of ERK activation in the behavioral sensitization induced by repeated administration of psychostimulants in mice, using SL327, a brain-penetrating selective inhibitor of MAP-kinase/ERK kinase (MEK), the enzyme that selectively activates ERK. A dose of SL327 (30 mg/kg) that reduced the number of activated ERK-positive neurons by 62 to 89% in various brain areas, had virtually no effect on the spontaneous locomotor activity or the acute hyperlocomotion induced by cocaine or D-amphetamine. Pre-treatment with SL327 (30 mg/kg) prior to each drug administration prevented the locomotor sensitization induced by repeated injections of D-amphetamine or cocaine. The SL327 pre-treatment abolished also conditioned locomotor response of mice placed in the context previously paired with cocaine or D-amphet...Continue Reading

References

Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Dec 24, 1997·Brain Research. Brain Research Reviews·R C Pierce, P W Kalivas
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Dec 14, 1999·Learning & Memory·J C SelcherJ D Sweatt
Jan 1, 1993·Behavioural Pharmacology·J. Stewart, A. Badiani
Oct 3, 2001·The American Journal on Addictions·E J Nestler
Oct 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eun Sang ChoeJohn Q Wang
Oct 1, 2003·British Journal of Pharmacology·Julie SalzmannFlorence Noble
Apr 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lu ZhangMing Xu
Apr 14, 2004·The European Journal of Neuroscience·Emmanuel ValjentJocelyne Caboche
Jul 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nobuyoshi SutoPaul Vezina
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anjali RajadhyakshaBarry E Kosofsky
Dec 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Emmanuel ValjentJean-Antoine Girault

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Citations

Oct 29, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nikhil M UrsMarc G Caron
Jan 6, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emmanuel DarcqBrigitte L Kieffer
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica J HawesMarina R Picciotto
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Greer S KirshenbaumJohn C Roder
May 27, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Chunping LiJianwei Zhou
Dec 7, 2013·Science·Chan Lek TanAnne Schaefer
Feb 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael W ShiflettBernard W Balleine
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan-Qin LiLin Lu
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Derek P DiRoccoDaniel R Storm
Aug 2, 2015·The International Journal of Neuropsychopharmacology·Adrian M GomezJun Zhu
Nov 21, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jean TerrierVincent Pascoli
Mar 19, 2015·Frontiers in Cellular Neuroscience·Fabrizio Gardoni, Camilla Bellone
Jan 23, 2015·Frontiers in Molecular Neuroscience·Nicolas MassalyLionel Moulédous
Sep 18, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alfredo Ramos-MiguelJesús A García-Sevilla
Aug 24, 2010·Neuroscience and Biobehavioral Reviews·Yan-Chun Li, Wen-Jun Gao
Oct 17, 2016·The International Journal of Neuropsychopharmacology·Hanne Mette HoffmannMichel Vignes
Jan 5, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lindsey B KuiperLique M Coolen
Nov 7, 2006·Trends in Neurosciences·Lin LuYavin Shaham
Feb 24, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Seungwoo KimJeong-Hoon Kim
Oct 5, 2006·Journal of Neurochemistry·John Q WangLimin Mao
Jan 25, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanni HernandezDaniel Lévesque
Mar 18, 2008·British Journal of Pharmacology·M J ThomasY Shaham
Mar 24, 2009·Alcoholism, Clinical and Experimental Research·Catherine VilpouxMickael Naassila
Jun 18, 2009·Journal of Neuroscience Research·Chun-Hui JinHyoung-Chun Kim
May 17, 2008·Addiction Biology·Joost WiskerkeTaco J De Vries
Nov 1, 2011·The European Journal of Neuroscience·Tanya L DaigleMarc G Caron
Feb 10, 2011·Pharmacological Reviews·Jean-Martin Beaulieu, Raul R Gainetdinov

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Methods Mentioned

BETA
confocal microscopy

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