PMID: 6166707Apr 1, 1981Paper

Role of the H-2 complex in induction of T helper cells in vivo. II Negative selection of discrete subgroups of T cells restricted by I-A and I-A/E determinants

The Journal of Experimental Medicine
J Sprent, B Alpert

Abstract

Previous studies have shown that negative selection of T cells to sheep erythrocytes (SRC) after adoptive transfer to irradiated mice requires a sharing of H-2 determinants between the donor T cells and the selection hosts. This paper examines which part of the H-2 complex controls selection. The results show that, in the case of T cells of the H-2k haplotype, complete selection occurs with donor host matching limited to the I-A through I-E subregions of the H-2 complex. Selection to SRC was partial in I-A compatible, I-E incompatible hosts, minimal or not detectable in I-A incompatible, I-E compatible hosts, but near-complete in hosts matched at both the I-A and I-E subregions. Consecutive selection in hosts matched solely at (a) the I-A subregion and (b) the I-E subregion led to incomplete selection. From these and other findings it is argued that H-2k T cells comprise a mixture of T cells restricted by I-A and I-A/E hybrid molecules.

References

Jan 1, 1976·Transplantation Reviews·C S David
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·B Benacerraf, M E Dorf
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C G Fathman, H Hengartner
Oct 1, 1978·The Journal of Experimental Medicine·P P JonesH O McDevitt
Oct 19, 1979·Science·J W UhrR G Cook
Apr 1, 1976·The Journal of Experimental Medicine·D H KatzB Benacerraf
Oct 1, 1980·The Journal of Experimental Medicine·E A LernerD B Murphy

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Citations

Aug 1, 1980·Springer Seminars in Immunopathology·J SprentK Molnar-Kimber

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