Role of the IBD5 susceptibility locus in the inflammatory bowel diseases

Inflammatory Bowel Diseases
Claudia Reinhard, John D Rioux

Abstract

The field of inflammatory bowel disease genetics plays a leading role in the genetics of complex traits. One of the first genetic loci for a complex trait to be identified by genome-wide linkage scans and confirmed by multiple studies was IBD1 for Crohn's disease. Shortly after this initial success, a second susceptibility locus, the IBD5 risk haplotype, was discovered and unequivocally replicated. In this review, we examine the genetics and potential functional implications of the IBD5 locus on disease susceptibility, prognosis, classification, and treatment. In addition, we discuss the challenges faced when the region identified by association contains multiple genes that are not easily separated by recombination-the primary tool of the human geneticist.

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Citations

Nov 26, 2010·The Journal of Biological Chemistry·Shehzad Z SheikhScott E Plevy
May 21, 2009·Annual Review of Genomics and Human Genetics·Johan Van LimbergenJack Satsangi
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Feb 20, 2007·Inflammatory Bowel Diseases·Giovanni LatellaRenzo Caprilli
Jan 9, 2007·Inflammatory Bowel Diseases·Johan Van LimbergenJack Satsangi
Sep 27, 2007·The American Journal of Gastroenterology·Johan Van LimbergenJack Satsangi
Aug 2, 2007·Journal of Pediatric Gastroenterology and Nutrition·Anna LatianoVito Annese

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