Role of the increase in p21 in cisplatin-induced acute renal failure in rats.

Journal of the American Society of Nephrology : JASN
Takehiko MiyajiAkira Hishida

Abstract

The goal of this study was to clarify the role of p21, a cyclin-dependent kinase inhibitor, in acute renal failure (ARF). This was accomplished with the examination of the renal expression of p21 in cisplatin (CDDP)-induced ARF and in rechallenge injury with CDDP. The injection of CDDP (5 mg/kg) into rats induced increases in serum creatinine and tubular damage and the number of in situ DNA nick end labeling-positive cells, which peaked at day 5, followed by recovery to control levels by day 14. The rechallenge with the same dose of CDDP 14 d after the first dose of CDDP induced significantly less injury and no significant increase in in situ DNA nick end labeling-positive cells. The first CDDP dose significantly increased p53-positive nuclei at day 1, which disappeared by day 5, and the number of p21-positive nuclei, which had two peaks on days 3 and 9. The number of proliferating cell nuclear antigen (PCNA)-positive nuclei peaked at days 3 and 12. A significant increase in the incorporation of 5-bromo 2'-deoxyuridine (BrdU) was found at day 5 and peaked at day 7. The second injection of CDDP induced significant increases in the number of p21-, p53-, and PCNA-positive nuclei within 2 d but did not affect the incorporation of B...Continue Reading

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Citations

Sep 19, 2003·Seminars in Nephrology·Peter M PriceRobert L Safirstein
Oct 13, 2004·Toxicology and Applied Pharmacology·Hua ZhouAkira Hishida
Aug 26, 2004·Kidney International·Marjanka C LuijerinkInge E T van den Berg
Jul 16, 2004·Kidney International·Peter M PriceRobert L Saf Irstein
Feb 10, 2006·American Journal of Physiology. Renal Physiology·Hua ZhouAkira Hishida
Jul 28, 2021·Life Sciences·Shogo ShimizuMotoaki Saito
Jun 5, 2007·Life Sciences·Yoshihiko ShibayamaKatsushi Yamada
Jun 11, 2019·Life Sciences·Carolina Martinez RomãoLuzia Naôko Shinohara Furukawa
Apr 4, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jinghui LuoAkira Hishida
May 30, 2008·Kidney International·Hua ZhouRobert A Star
Aug 7, 2008·The Journal of Pharmacology and Experimental Therapeutics·Man Jiang, Zheng Dong
May 9, 2009·Journal of the American Society of Nephrology : JASN·Xiaobin HanRussell W Chesney
Jun 19, 2009·Kidney International·Peter M PriceJudit Megyesi
Jan 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Flavia KfouriLuis Yu
Oct 21, 2021·Clinics·Cassiane Dezoti da FonsecaMaria de Fatima Fernandes Vattimo
Jan 22, 2011·British Journal of Pharmacology·Shogo ShimizuKeisuke Satoh
Jan 25, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Emi YamamatoJyoji Yamate

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