Role of the inflammasome in myocardial infarction

Trends in Cardiovascular Medicine
Masafumi Takahashi

Abstract

Inflammation plays a crucial role in the pathophysiology of myocardial infarction (MI). In particular, reperfusion caused by increased thrombolytic activity or revascularization therapy may restore the coronary blood flow and reduce the infarct size, but it also simultaneously enhances the inflammatory response and causes harmful effects on the myocardium-a process termed ischemia-reperfusion (I/R) injury. The inflammasome is a large multiprotein complex that is formed in the cytosol in response to danger signals; it drives the proinflammatory cytokine interleukin (IL)-1β. Increasing evidence indicates that the inflammasome is a key player in the disease processes of sterile inflammation. In particular, IL-1β is a prominent and early mediator of inflammation in I/R injury, suggesting the importance of the inflammasome in myocardial I/R injury. This article reviews the role of the inflammasome in the development of myocardial I/R injury and discusses the potential of the inflammasome as a novel therapeutic target for the treatment of myocardial I/R injury.

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Citations

Mar 19, 2014·International Heart Journal·Masafumi Takahashi
Mar 19, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xuan LiZiad Mallat
Jun 6, 2015·Scientific Reports·Takanori KomadaMasafumi Takahashi
Mar 13, 2014·The American Journal of Pathology·Takanori KomadaMasafumi Takahashi
Apr 30, 2016·Oxidative Medicine and Cellular Longevity·Letteria MinutoliDomenica Altavilla
Oct 21, 2014·Antioxidants & Redox Signaling·Justine M AbaisPin-Lan Li
Oct 28, 2016·Journal of Cellular and Molecular Medicine·Yaqiong WangJunbo Ge
Nov 8, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Fumitake UsuiMasafumi Takahashi
Oct 30, 2018·Journal of Cellular Physiology·Koumei ShirasunaMasafumi Takahashi
Oct 17, 2018·Canadian Journal of Physiology and Pharmacology·Ahmed M DarweshJohn M Seubert
Apr 2, 2019·Biological & Pharmaceutical Bulletin·Masafumi Takahashi
May 19, 2017·The Journal of Reproduction and Development·Kotomi SenoKoumei Shirasuna
Aug 17, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Paras K MishraTakashi Matsui
Apr 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshiyuki InoueMasafumi Takahashi
Nov 17, 2017·Basic Research in Cardiology·Xavier Rossello, Derek M Yellon
Mar 13, 2020·Frontiers in Endocrinology·Koumei ShirasunaMasafumi Takahashi
Dec 31, 2014·The Journal of Biological Chemistry·Yoshiko MizushinaMasafumi Takahashi
Dec 11, 2017·Basic Research in Cardiology·Dongling LiuXianwei Wang

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