Role of the junctional epithelium in periodontal innate defense and homeostasis

Journal of Periodontal Research
Y TsukamotoM Nakamura

Abstract

The junctional epithelium provides the front-line defense against periodontal bacterial infection. The migration of neutrophils into the junctional epithelium might represent a protective reaction against bacterial infections. However, neutrophils penetrate into the junctional epithelium even under sterile conditions. In this study, we analyzed and compared the number of neutrophils and the cytokine expression related to neutrophil migration in the junctional epithelium in conventional and germ-free mice. Germ-free and conventional ICR mice were used at 12 wk of age. Frozen sections were used for the detection of Gr-1, macrophage inflammatory protein-2 (MIP-2/CXCL2) and proliferating cell nuclear antigen-positive cells in the two groups of mice. Laser capture microdissection and RT-PCR analysis were used to evaluate the expression of keratinocyte-derived chemokine (KC/CXCL1), MIP-2, interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) mRNAs in the two groups of mice. Morphometric examination indicated an increase in the area of the junctional epithelium upon bacterial infection. Immunohistochemical studies also detected an increased number of neutrophils in the junctional epithelium upon bacterial infection. Higher up-reg...Continue Reading

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Citations

May 3, 2014·Scientific Reports·Sara Yajima-HimuroMatsuo Yamamoto
Aug 13, 2013·Periodontology 2000·Ara GreerRichard P Darveau
Feb 26, 2013·Cellular Microbiology·Camille ZenobiaRichard P Darveau
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Sep 29, 2020·Journal of Dental Research·X YuanJ A Helms
Jan 16, 2021·Dentistry Journal·Yusuke MakinoMasanori Nakamura
Jan 23, 2021·Journal of Personalized Medicine·Yu Gyung KimDo-Yeon Kim
Mar 11, 2021·Periodontology 2000·Matsuo Yamamoto, Ryo Aizawa
Mar 11, 2021·Periodontology 2000·Ana M ChangRichard P Darveau
Mar 11, 2021·Periodontology 2000·Richard P Darveau, Michael A Curtis
Jul 2, 2021·Proceedings of the National Academy of Sciences of the United States of America·Shatha BamashmousRichard P Darveau

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