Role of the KCNJ Gene Variants in the Clinical Outcome of Type 1 Diabetes.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
Annalisa BlasettiLiborio Stuppia

Abstract

Diabetes is considered as a disease with a wide and continuous clinical spectrum, ranging from Type 1 (T1D) and Type 2 Diabetes (T2D) with complex multifactorial causes. In the last years, particular attention has been focused on the predictive value and therapeutic potential of single nucleotide polymorphisms (SNPs). SNPs can alter the seed-sequence in miRNA's loci and miRNA target sites causing changes in the structure and influencing the binding function. Only few studies have investigated the clinical influence of SNPs, in particular potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ) gene variants in T1D population. The aim of the study is to investigate the occurrence and the possible metabolic significance of KCNJ polymorphism in a group of pediatric patients with T1D. The study was performed in a cohort of 90 Caucasian children and adolescents with T1D and 93 healthy subjects. Rs5210 polymorphism has been analyzed with a prevalence of the GG genotype in the patient group suggesting its association with T1D. Therefore, a relationship was found between GG genotype and body mass index (BMI) at diagnosis and insulin requirement (IR) after 6 months. The study suggested an action for rs5210 in determining the...Continue Reading

References

Oct 14, 2004·Diabetologia·S FourlanosL C Harrison
Mar 1, 2006·Diabetes Care·Samy MrenaMikael Knip
Jun 4, 2010·The Journal of Physiology·James S McTaggartFrances M Ashcroft
Oct 12, 2010·Nature Genetics·Elizabeth K SpeliotesRuth J F Loos
Jun 4, 2011·Diabetes Care·Dana DabeleaUNKNOWN SEARCH for Diabetes in Youth Study
Feb 2, 2012·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Mustafa Abdo Saif DehwahQingyang Huang
Sep 11, 2012·Pediatric Diabetes·Maki MoritaniUNKNOWN Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT)
Oct 30, 2012·Diabetes Research and Clinical Practice·M Lucrecia Alvarez, Johanna K Distefano
Sep 26, 2013·Genetics and Molecular Research : GMR·L J QinQ Y Huang
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Aug 15, 2014·Clinical and Experimental Pharmacology & Physiology·Qing LiWeiping Jia
Jan 28, 2015·Advanced Biomedical Research·Ali RastegariFatemeh Moazen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Endocrinology and Metabolism Clinics of North America
David M MaahsElizabeth J Mayer-Davis
Current Diabetes Reports
Mireia Ramos-RodríguezLorenzo Pasquali
© 2021 Meta ULC. All rights reserved