Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice

Scientific Reports
Aleksandra BednarzMałgorzata Lenartowicz

Abstract

Moderate intravascular hemolysis is a common condition in newborns. It is followed by the accumulation of bilirubin, which is a secondary product of the activity of heme oxygenase-1, an enzyme that catalyzes the breakdown of heme released from disrupted erythrocytes and taken up by hepatic macrophages. Although these cells are a major site of enzymatic heme breakdown in adults, we show here that epithelial cells of proximal tubules in the kidneys perform the functions of both heme uptake and catabolism in mouse neonates. A time-course study examining mouse pups during the neonatal period showed a gradual recovery from hemolysis, and concomitant decreases in the expression of heme-related genes and non-heme iron transporters in the proximal tubules. By adjusting the expression of iron-handling proteins in response to the disappearance of hemolysis in mouse neonates, the kidneys may play a role in the detoxification of iron and contribute to its recirculation from the primary urine to the blood.

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Citations

Nov 27, 2019·Toxins·Marie FrimatLubka T Roumenina
Oct 24, 2020·International Journal of Molecular Sciences·Aleksandra BednarzMałgorzata Lenartowicz

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Methods Mentioned

BETA
confocal microscopy
dissection
electrophoresis
PCR
light microscopy

Software Mentioned

Zeiss ZEN
Quantity One
ImageJ

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