Role of the liver in peripheral tolerance: induction through oral antigen feeding

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Wei LiJames D Perkins

Abstract

Using a murine liver transplant model, we studied the liver's role in peripheral tolerance. Livers from BALB/c mice fed with ovalbumin (OVA) at either a low or high dose were transplanted into syngeneic recipients. Non-fed recipients were controls. Orthotopic liver transplantation (OLTx) was followed by OVA immunization and delayed-type hypersensitivity (DTH) challenge. The ex vivo adoptive transfer effect of liver nonparenchymal cells (NPCs) or spleen cells (SCs) from OVA-fed mice was examined. In vitro proliferative assays and cytokine profiles were conducted on NPCs and SCs from transplant recipients. Livers from all OVA-fed mice after 10 days transferred tolerance to OVA-naïve mice. The time course of adoptive transfer of liver NPCs from high-dose OVA-fed mice transferred OVA tolerance within 24 h; low-dose OVA-fed mice required > or = 4 days to transfer tolerance. The in vitro proliferative response of the NPCs to OVA revealed a decreased response in both dosage groups over the control group. Our results suggest that the liver plays an important role in inducing peripheral tolerance in a mucosal tolerance model, especially feeding high-dose OVA.

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Citations

Sep 23, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christal C Bowman, MaryJane K Selgrade
Jan 30, 2014·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Hongyu LiuWei Li
Aug 19, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Daniel D HamptonJane E Onken
Jul 12, 2011·Cellular Microbiology·Maria Rescigno
Sep 16, 2008·Immunity·Anne GoubierDominique Kaiserlian
Sep 16, 2005·European Journal of Immunology·Andreas LimmerPercy A Knolle
Nov 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antonino CastellanetaAngus W Thomson
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rifaat SafadiScott L Friedman
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan K BlissJudith A Appleton
Aug 22, 2021·Cellular & Molecular Immunology·Laura A HuppertJames C Lee

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