PMID: 7539347Jun 1, 1995Paper

Role of the low zinc bioavailability on cellular immune effectiveness in cystic fibrosis

Clinical Immunology and Immunopathology
E MocchegianiN Fabris

Abstract

An altered cellular immune response as a secondary phenomenon has been suggested to be probably involved in the bronchopulmonary infections by Pseudomonas aeruginosa in cystic fibrosis (CF). The difficulty to eradicate with modern anti-pseudomonal antibiotics the bronchopulmonary infections has led us to further investigate the possible existence of other cellular immune defects and their cause. Alterations in zinc turnover are present in CF. Zinc is relevant for good immune functioning. In particular, zinc is required to confer biological activity to thymulin (ZnFTS), a biochemically defined thymic hormone with a modulating action on cell-mediated immunity. The zinc-unbound form (FTS) is inactive and it can be unmasked by in vitro zinc addition to the plasma samples revealing the total amount of circulating thymulin (active + inactive). Marginal zinc deficiencies may prevent peripheral biological activation of active thymulin. Total zinc-saturable thymulin fractions in CF are similar to those observed in normal subjects, whereas the active quota is strongly reduced associated with concomitant high plasma levels of inactive thymulin compared to the values of healthy children (P < 0.01). A strict correlation exists between zinc ...Continue Reading

Citations

Dec 4, 2002·Pediatric Pulmonology·Leyla AkanliAllen J Dozor
Apr 1, 1995·Aging : Clinical and Experimental Research·N Fabris, E Mocchegiani
Nov 26, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Veronic DamphousseGenevieve Mailhot
Dec 19, 2003·Metabolism: Clinical and Experimental·Kristin BestRobert A Disilvestro
Jul 31, 1998·Nutrition·J Levy
Jul 5, 2006·Journal of Pediatric Gastroenterology and Nutrition·Asim MaqboolVirginia A Stallings
Aug 6, 2000·Pediatric Research·N F KrebsK M Hambidge
Nov 26, 2009·Pediatric Clinics of North America·Suzanne H MichelMaria Mascarenhas
May 10, 2000·The Journal of Nutrition·E Mocchegiani, M Muzzioli
Aug 15, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H CalumN Høiby

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