Role of the lung in total body clearance of circulating drugs

Clinical Pharmacokinetics
R A Roth, D A Wiersma

Abstract

Attention in recent years has focused upon the ability of lung to accumulate and/or to metabolise circulating hormones, drugs and other xenobiotic agents. Although often studied in broken cell preparations, such functions must be examined in intact lung before extrapolation to the situation in vivo is possible. The role of lung in total body clearance of xenobiotic agents is often considered to be small, as compared with the liver it usually has much lower concentrations of degradative enzymes and a smaller mass. However, consideration of such factors as organ blood flow or stimulation of drug metabolising enzymes suggests that the contribution of the lung to total body clearance of some drugs is greater than previously recognised. This may explain some of the alterations in drug clearance seen clinically. For example, cigarette smoking may increase the clearance of certain xenobiotic compounds by stimulating pulmonary drug metabolising enzymes. Pulmonary drug disposition may also be altered by conditions affecting cardiac output, such as exercise, hypoxia, and circulatory shock, or those affecting acid-base balance, such as hyperventilation. In addition, pneumotoxicants may affect pulmonary clearance of circulating drugs and x...Continue Reading

References

Jan 1, 1986·European Journal of Clinical Pharmacology·M P PerssonL Paalzow
Jan 1, 1983·Chemico-biological Interactions·D A WiersmaR A Roth
Jul 1, 1999·Clinical and Experimental Pharmacology & Physiology·R N Upton, D J Doolette
Jan 1, 1982·Journal of Toxicology and Environmental Health·K M McCormackJ B Hook
Apr 1, 1996·Acta Anaesthesiologica Scandinavica·K HasegawaM Fujimori
Oct 1, 1987·British Journal of Industrial Medicine·W E Pepelko
Mar 1, 1988·Archives internationales de physiologie et de biochimie·F W van SchaikG H Huisman
Mar 15, 1989·Toxicology and Applied Pharmacology·M G BarronW L Hayton
May 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·D A Rosen, K R Rosen
Feb 1, 1988·British Journal of Clinical Pharmacology·M P PerssonL Paalzow
Oct 18, 2011·Toxicology and Applied Pharmacology·Susan Ritger CrowellRichard A Corley
Nov 1, 1988·Biopharmaceutics & Drug Disposition·A C MacIntyre, D J Cutler
Jan 1, 1986·Lung·J A PangD M Geddes
Mar 14, 2000·Acta Anaesthesiologica Scandinavica·B Mets
May 1, 1981·Critical Reviews in Toxicology·M E Andersen
Jan 1, 1989·The American Journal of Physiology·R KamejiD E Rannels

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