Role of the M2 haplotype within the annexin A5 gene in the occurrence of pregnancy-related venous thromboembolism

American Journal of Obstetrics and Gynecology
Elvira GrandoneMaurizio Margaglione

Abstract

Knowledge about risk factors for venous thromboembolism (VTE) is still limited. A recently found haplotype within the natural anticoagulant protein annexin A5 (ANXA5) exerts an important modulating effect on gene expression. Eighty-three nonanticoagulated patients with a documented pregnancy-related VTE and 195 controls were investigated. The presence of the ANXA5 haplotypes was determined. Twenty-seven patients (32.5%) carried the M2 haplotype. Among them, 17 (63.0%) had a history of VTE in puerperium and 10 (37.0%) during pregnancy. The prevalence of the M2 haplotype was different as compared with that recorded among controls (odds ratio, 2.7; 95% confidence interval, 1.5-4.9, P < .001). A logistic regression analysis, correcting for potential confounders (age at which the thrombotic event occurred, factor V Leiden, and factor IIA20210 variants) showed a significant increase (odds ratio, 3.4; 95% confidence interval, 1.7-6.7) of the occurrence of VTE in carriers of the M2 haplotype as compared with noncarriers. The M2 haplotype within the ANXA5 gene may represent a new thrombophilic risk factor for pregnancy-related VTE.

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Citations

Jul 15, 2015·Expert Opinion on Pharmacotherapy·Elvira GrandoneGiovanni L Tiscia
Dec 17, 2014·Thrombosis Research·Larissa HiddinkWaander L van Heerde
Jul 16, 2013·Fertility and Sterility·Yuko HayashiMayumi Sugiura-Ogasawara
Dec 17, 2014·Journal of Thrombosis and Haemostasis : JTH·A E A DahmP M Sandset
Jul 26, 2011·American Journal of Obstetrics and Gynecology·Beverley J HuntJacob H Rand
Dec 7, 2019·Current Rheumatology Reports·Lourdes Ortiz-Fernández, Amr H Sawalha
Sep 11, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·G DryllisM Politou
Nov 11, 2014·British Journal of Haematology·Paulien G de JongSaskia Middeldorp
Nov 25, 2020·Journal of Assisted Reproduction and Genetics·Nina RogenhoferChristian Thaler
Feb 17, 2021·Thrombosis and Haemostasis·Marisol Herrera-RiveroUlrike Nowak-Göttl

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