PMID: 8962649Mar 1, 1996Paper

Role of the major histocompatibility complex region in reproduction, cancer, and autoimmunity

American Journal of Reproductive Immunology : AJRI
T J Gill

Abstract

A diverse body of evidence indicates that there is an association among reproductive failure, development, cancer, and autoimmunity. The evidence for the relationship of genes linked to the major histocompatibility complex to these diseases will be evaluated. The published results of both experimental studies in animals and of clinical observations in humans will be summarized and analyzed. Experimental studies in the rat have demonstrated a relationship between the MHC-linked region and growth, development, and susceptibility to chemical carcinogens. Data from other species support these observations. Clinical studies in humans have demonstrated an association between the MHC region and recurrent spontaneous abortions and a variety of other diseases; between recurrent spontaneous abortion and several autoimmune diseases; and between isolated populations and deficiencies of HLA homozygotes. Genes in the MHC-linked region play an important role in the control of reproduction, growth and development, and susceptibility to a variety of diseases.

References

Jul 1, 1990·American Journal of Obstetrics and Gynecology·H N HoT Y Lee
Jan 1, 1983·Transplantation·T J Gill
Jul 15, 1984·International Journal of Cancer. Journal International Du Cancer·K N RaoT J Gill
Sep 1, 1994·American Journal of Reproductive Immunology : AJRI·A J SheltonT J Gill
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M F MelhemT J Gill

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Citations

Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·K YamazakiE A Boyse
May 13, 1999·Immunological Reviews·S MikkoL Andersson
Jan 1, 1997·American Journal of Reproductive Immunology : AJRI·T J Gill
Oct 9, 1998·American Journal of Reproductive Immunology : AJRI·J C CooperG B Dealtry
Sep 3, 2014·Biomedical Journal·Daniel Vaiman

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