PMID: 9171922Feb 1, 1997Paper

Role of the mitochondrial permeability transition pore in apoptosis

Bioscience Reports
T HirschG Kroemer

Abstract

Mitochondrial permeability transition (PT) involves the formation of proteaceous, regulated pores, probably by apposition of inner and outer mitochondrial membrane proteins which cooperate to form the mitochondrial megachannel (= mitochondrial PT pore). PT has important metabolic consequences, namely the collapse of the mitochondrial transmembrane potential, uncoupling of the respiratory chain, hyperproduction of superoxide anions, disruption of mitochondrial biogenesis, outflow of matrix calcium and glutathione, and release of soluble intermembrane proteins. Recent evidence suggests that PT is a critical, rate limiting event of apoptosis (programmed cell death): (i) induction of PT suffices to cause apoptosis; (ii) one of the immediate consequences of PT, disruption of the mitochondrial transmembrane potential (delta psi m), is a constant feature of early apoptosis; (iii) prevention of PT impedes the delta psi m collapse as well as all other features of apoptosis at the levels of the cytoplasma, the nucleus, and the plasma membrane; (iv) PT is modulated by members of the apoptosis-regulatory bcl-2 gene family. Recent data suggest that the acquisition of the apoptotic phenotype, including characteristic changes in nuclear morph...Continue Reading

Citations

Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·J M JürgensmeierJ C Reed
Jun 13, 1998·The Journal of Biological Chemistry·J Cai, D P Jones
Mar 23, 2004·Annals of the New York Academy of Sciences·Alessandra Pagano, Constance Barazzone-Argiroffo
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Olena YermolaievaToshinori Hoshi
Jul 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaocun Sun, Michael B Zemel
Jan 22, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Yoshinori KobayashiShumpei Yokota
Jun 16, 2005·Experimental Biology and Medicine·Charles R GoodlettFeng C Zhou
Jul 13, 2007·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Akihito Nakai
Apr 20, 2011·Plant Foods for Human Nutrition·Jun-Xia XiaoHong-Wei Qiu
Jul 20, 2016·International Journal of Molecular Medicine·Bin LiRuijie Xie
Sep 20, 2016·Reproduction in Domestic Animals = Zuchthygiene·Y NiuD Zhang
Aug 17, 2019·EMBO Reports·Isabel Gordaliza-AlagueroAntonio Zorzano
Sep 25, 1999·The Journal of Biological Chemistry·D L BrattonP M Henson
Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·D W VoehringerL A Herzenberg
Oct 7, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alessandra PaganoConstance Barazzone Argiroffo
Oct 29, 2003·Antioxidants & Redox Signaling·Christopher J LievenLeonard A Levin
Apr 18, 2008·Journal of Applied Toxicology : JAT·T J MillerJ P Hanig
Sep 13, 2012·Journal of Biomedical Materials Research. Part a·Liyan QiuQinghe Zhao
Apr 25, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Noriyuki TakaiHisashi Narahara
Dec 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sangiliyandi GurunathanJin-Hoi Kim
Sep 14, 2014·Journal of Bioenergetics and Biomembranes·Juan Carlos Corona, Michael R Duchen
Jun 6, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Fatih Ozaltin
Jan 8, 2005·Cell Death and Differentiation·T A PrechtK A Heidenreich
Sep 3, 2009·Annals of the New York Academy of Sciences·Claudia CerellaLina Ghibelli

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