Role of the multidomain protein spinophilin in blood pressure and cardiac function regulation.

Hypertension
Andrey C da Costa-GoncalvesVolkmar Gross

Abstract

Spinophilin controls intensity/duration of G protein-coupled receptor signaling and thereby influences synaptic activity. We hypothesize that spinophilin affects blood pressure through central mechanisms. We measured blood pressure and heart rate in SPL-deficient (SPL(-/-)), heterozygous SPL-deficient (SPL(+/-)), and wild-type (SPL(+/+)) mice by telemetry combined with fast Fourier transformation. We also assessed peripheral vascular reactivity and performed echocardiography. SPL(-/-) had higher mean arterial pressure than SPL(+/-) and SPL(+/+) (121+/-2, 112+/-1, and 113+/-1 mm Hg). Heart rate was inversely related to spinophilin expression (SPL(-/-) 565+/-0.4, SPL(+/-) 541+/-5, SPL(+/+) 525+/-8 bpm). The blood pressure response to prazosin, trimethapane, and the heart rate response to metoprolol were stronger in SPL(-/-) than SPL(+/+) mice, whereas heart rate response to atropine was attenuated in SPL(-/-). Mesenteric artery vasoreactivity after angiotensin II, phenylephrine, and the thromboxane mimetic (U46619) as well as change in heart rate, stroke volume, and cardiac output after dobutamine were similar in SPL(-/-) and SPL(+/+). Baroreflex sensitivity was attenuated in SPL(-/-) compared with SPL(+/-) and SPL(+/+), which wa...Continue Reading

References

Jan 1, 1989·Clinical and Experimental Pharmacology & Physiology. Supplement·E M Krieger
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·P B AllenP Greengard
Aug 27, 1999·Trends in Pharmacological Sciences·J R Hepler
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·J FengP Greengard
Jan 23, 2001·The Journal of Biological Chemistry·J G RichmanL E Limbird
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Y F LiK P Patel
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ben J A Janssen, Jos F M Smits
Oct 12, 2002·The Journal of Biological Chemistry·Qin Wang, Lee E Limbird
Feb 18, 2003·The Journal of Clinical Investigation·Scott P HeximerKendall J Blumer
May 10, 2003·The Journal of Biological Chemistry·Ashley E BradyLee E Limbird
Mar 31, 2004·Hypertension·Gianfranco ParatiUNKNOWN European Society of Hypertension Working Group on Blood Pressure and Heart Rate Variability
Jan 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Volkmar GrossFriedrich C Luft
Aug 17, 2006·American Journal of Physiology. Renal Physiology·Jakob NielsenSøren Nielsen
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Wenhua LiuZhen Yan
Feb 7, 2007·Biochemistry·Matthew S KelkerWolfgang Peti
Jul 24, 2007·Experimental Physiology·Hantz C HerculeVolkmar Gross
Sep 29, 2007·Canadian Journal of Physiology and Pharmacology·Veronica A PeottaSilvana S Meyrelles
Jan 24, 2008·Hypertension·David E StecTrinity Vera
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·Dominique LaudeJean-Luc Elghozi

❮ Previous
Next ❯

Citations

Jun 3, 2010·Journal of Visualized Experiments : JoVE·Mark D McCauley, Xander H T Wehrens
Dec 17, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Aline M HilzendegerMichael Bader
Aug 6, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Andrey C da Costa GoncalvesVolkmar Gross
Oct 10, 2015·Stroke; a Journal of Cerebral Circulation·Odilo EngelAndreas Meisel
Jul 1, 2020·American Journal of Physiology. Endocrinology and Metabolism·Yong ZhangHongjun Wang
Mar 27, 2010·Sleep·Alessandro SilvanIGiovanna Zoccoli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Volkmar GrossFriedrich C Luft
IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society
Dominique LaudeJean-Luc Elghozi
International Journal of Obesity : Journal of the International Association for the Study of Obesity
P WellhönerC Dodt
© 2022 Meta ULC. All rights reserved