Role of the N, N'-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone

Reproduction : the Official Journal of the Society for the Study of Fertility
Valeria A SanderAlicia B Motta

Abstract

The present study investigated the role of the N, N{'}-dimethylbiguanide metformin (50 mg/100 g body weight in 0.05 ml water, given orally with a canulla) in the prevention of endocrine and immune disorders provoked by the hyperandrogenization with dehydroepiandrosterone (DHEA) in prepuberal BALB/c mice. The treatment with DHEA (6 mg/100 g body weight in 0.1 ml oil) for 20 consecutive days, recreates a mouse model that resembles some aspects of the human polycystic ovary syndrome (PCOS). The treatment with DHEA did not modify either body mass index (BMI) or blood glucose levels, but did increase fasting insulin levels when compared with controls. Markers of ovarian function - serum estradiol (E), progesterone (P) and ovarian prostaglandin E (PGE) - were evaluated. The treatment with DHEA increased serum E and P levels while ovarian PGE diminished. When metformin was administered together with DHEA, serum insulin, E and P levels, and ovarian PGE values did not differ when compared with controls. Using flow cytometry assays we found that the treatment with DHEA diminished the percentage of the CD4 + T lymphocyte population and increased the percentage of the CD8 + T lymphocyte population from both ovarian tissue and retroperitone...Continue Reading

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Citations

Oct 10, 2008·Reproduction, Fertility, and Development·Valeria A SanderAlicia B Motta
Jun 2, 2009·Molecular Human Reproduction·Evelin Mariel EliaAlicia Beatriz Motta
Aug 19, 2011·Reproductive Biology and Endocrinology : RB&E·Norbert GleicherDavid H Barad
Jun 9, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Valeria A SanderAlicia B Motta
Mar 13, 2014·Reproductive Biology·E Leonie A F van Houten, Jenny A Visser
Oct 16, 2009·Molecular Human Reproduction·Jia-Qiao ZhuQing-Yuan Sun
Jan 28, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Haolin ZhangJie Qiao
Jun 12, 2012·Reproductive Biomedicine Online·Norbert Gleicher, David H Barad
Nov 1, 2011·Fertility and Sterility·Renato FanchinJean-Marc Ayoubi
Dec 21, 2010·Fertility and Sterility·Héctor F Escobar-MorrealeFrank González
Mar 2, 2010·The Journal of Steroid Biochemistry and Molecular Biology·A B Motta
Apr 7, 2010·Reproductive Biomedicine Online·Denise BelgoroskyAlicia B Motta
Sep 27, 2008·International Immunopharmacology·Evelin EliaAlicia Beatriz Motta
Jun 14, 2008·Clinical and Experimental Immunology·M E SolanoA B Motta
Feb 24, 2016·Rejuvenation Research·Min Jung LeeIk-Hyun Cho
Sep 11, 2010·Fertility and Sterility·Roberta Rassi MahamedJosé Maria Soares
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Nov 8, 2018·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Yanhua ShiWei Wang

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