PMID: 9557738Apr 29, 1998Paper

Role of the N-terminal zinc finger of human immunodeficiency virus type 1 nucleocapsid protein in virus structure and replication

Journal of Virology
V TanchouJ L Darlix

Abstract

Nucleocapsid protein (NCp7) of human immunodeficiency virus type 1 is found covering the genomic RNA in the interior of the viral particle. It is a highly basic protein with two zinc fingers of the form CX2CX4HX4C which exhibit strong affinity for a zinc cation. To study the structure-function relationship of the N-terminal zinc finger of NCp7, this domain was either deleted or changed to CX2CX4CX4C. We examined virus formation and structure as well as proviral DNA synthesis. Our data show that these two NC mutations result in the formation of particles with an abnormal core morphology and impair the end of proviral DNA synthesis, leading to noninfectious viruses.

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Citations

May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·M C WilliamsV A Bloomfield
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·J P Moore, M Stevenson
May 21, 2005·AIDS·Alice M TangChristine Wanke
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Oct 12, 2016·Viruses·Lizna M AliFarah Mustafa
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Mar 8, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Lalit DeshmukhG Marius Clore
Apr 3, 2020·Biological Trace Element Research·Karen Cilliers, Christo J F Muller
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Aug 19, 2011·AIDS Research and Human Retroviruses·Abdul A Waheed, Eric O Freed
Aug 5, 2020·Antimicrobial Agents and Chemotherapy·Moisés A ÁrquezLuis Menéndez-Arias

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