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Role of the N-terminus in the interaction of pancreatic phospholipase A2 with aggregated substrates. Properties and crystal structure of transaminated phospholipase A2

Biochemistry

Jun 5, 1984

B W DijkstraA J Slotboom

PMID: 6466614

Abstract

A free N-terminal alpha-NH3+ group is absolutely required for full catalytic activity of phospholipase A2 on aggregated substrates. To elucidate how this alpha-NH3+ group triggers catalytic activity, we specifically transaminated this group in various pancreatic phospholipases A2. Porci...read more

Mentioned in this Paper

In Vivo NMR Spectroscopy
Phospholipase A2, human
Enzymes, antithrombotic
Plain X-ray
Pseudo brand of pseudoephedrine
Aggregation
Bos taurus
Dall Sheep
Genus equus
Fluorescence Spectroscopy
Paper Details
References
  • References21
  • Citations39
123
  • References21
  • Citations39
1234

Role of the N-terminus in the interaction of pancreatic phospholipase A2 with aggregated substrates. Properties and crystal structure of transaminated phospholipase A2

Biochemistry

Jun 5, 1984

B W DijkstraA J Slotboom

PMID: 6466614

DOI:

Abstract

A free N-terminal alpha-NH3+ group is absolutely required for full catalytic activity of phospholipase A2 on aggregated substrates. To elucidate how this alpha-NH3+ group triggers catalytic activity, we specifically transaminated this group in various pancreatic phospholipases A2. Porci...read more

Mentioned in this Paper

In Vivo NMR Spectroscopy
Phospholipase A2, human
Enzymes, antithrombotic
Plain X-ray
Pseudo brand of pseudoephedrine
Aggregation
Bos taurus
Dall Sheep
Genus equus
Fluorescence Spectroscopy
Paper Details
References
  • References21
  • Citations39
123
  • References21
  • Citations39
1234
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