Role of the newer p53 family proteins in malignancy

Apoptosis : an International Journal on Programmed Cell Death
M S Irwin, W G Kaelin

Abstract

The most recently identified members of the p53 family, p63 and p73, share certain structural and functional similarities with p53. Both p63 and p73 can bind to canonical p53-DNA-binding sites, transactivate the promoters of known p53 target genes and induce apoptosis. Despite these similarities there are many important differences. In contrast to p53, p63 and p73 give rise to multiple distinct protein isoforms that have different functional properties. Upstream signaling pathways involved in the activation of p63 and p73 differ from those involved in p53 activation. Only a subset of the DNA damaging agents that induce p53 can induce p73. Cellular and viral oncoproteins can discriminate between p53 and the newer family members. In addition, the levels of p63 and p73 are affected by certain states of cellular differentiation. Finally, it is becoming clear that the newest members of the p53 family are not classical tumor suppressor genes. In contrast to the high prevalence of p53 mutations in human cancers, p63 and p73 mutations are rare. Indeed, levels of p73 increase during malignant progression. In addition, unlike p53-/- mice, mice lacking p63 and p73 do not develop tumors, but instead have significant developmental abnormali...Continue Reading

Citations

Jun 26, 2002·Oncogene·Shu-Chen HsiehFung-Fang Wang
Jun 25, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Olca BasturkN Volkan Adsay
Nov 4, 2005·Biochemistry. Biokhimii︠a︡·A A Morgunkova
Oct 13, 2007·Molecular Carcinogenesis·M Fernanda LaraJesús M Paramio
Feb 11, 2014·Prion·Luciana P RangelJerson L Silva
Apr 12, 2016·Frontiers in Oncology·Maria FerraiuoloSabrina Strano
Dec 9, 2016·International Journal of Molecular Sciences·Stephen R ArmstrongRoger P Leng
Oct 16, 2019·Indian Journal of Pathology & Microbiology·Gulay TuranOzgur Kulahci
Oct 20, 2001·The Journal of Biological Chemistry·Yasushi SasakiTakashi Tokino
Jan 17, 2002·Human Mutation·Andrew C R MartinJanet M Thornton
Jan 7, 2005·The Journal of Biological Chemistry·Robert A JohnsonKathleen W Scotto
Jan 27, 2007·The American Journal of Surgical Pathology·Mohammad OthmanN Volkan Adsay
Aug 4, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Z LinI Kim
Jul 29, 2006·Journal of Gastroenterology and Hepatology·Fernando S RamalhoSérgio Zucoloto
Nov 10, 2009·Breast Cancer Research and Treatment·L HankerA Rody
Oct 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Vladimir A Belyi, Arnold J Levine
Dec 13, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Takashi KusakabeShioko Kimura
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·O B Poli NetoJ M de Andrade
Jun 17, 2005·Journal of Physiology and Biochemistry·M Gomez-LazaroJ Jordán
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·M LokshinC Prives
Jan 16, 2010·Biochemical Society Transactions·Simon S McDade, Dennis J McCance
Jul 18, 2012·Cellular and Molecular Life Sciences : CMLS·Stefano Bartesaghi, Paolo Salomoni
Jun 4, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T OkumuraK Tsukada
Feb 12, 2010·Journal of Translational Medicine·Marta Herreros-VillanuevaMaría J Coma del Corral
Apr 23, 2011·Journal of Cell Science·Simon S McDadeDennis J McCance
Jun 10, 2010·Journal of Biomedical Science·László OroszKlára Megyeri
Jun 21, 2012·Genes & Development·William A Freed-Pastor, Carol Prives

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